SCHEMBL28619622

SCHEMBL28619622

O=C1c2ccc(Cl)cc2C(c2ccccc2)C1c1ccccc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 1/20 0.43
S100A4 P26447 2/20 0.42
CACNB4 O00305 1/20 0.41
CACNA1A O00555 1/20 0.41
CACNA1G O43497 1/20 0.41
CACNG3 O60359 1/20 0.41
CACNA1F O60840 1/20 0.41
CACNA1H O95180 1/20 0.41
CACNB3 P54284 1/20 0.41
CACNA2D1 P54289 1/20 0.41
CACNG7 P62955 1/20 0.41
CACNA1B Q00975 1/20 0.41
CACNA1D Q01668 1/20 0.41
CACNB1 Q02641 1/20 0.41
CACNG1 Q06432 1/20 0.41
CACNB2 Q08289 1/20 0.41
CACNA1S Q13698 1/20 0.41
CACNA1C Q13936 1/20 0.41
CACNA1E Q15878 1/20 0.41
CACNA2D4 Q7Z3S7 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28614063 0.79 CYP1A2 (0.44) CYP19A1S100A4MAPTLMNATP53
SCHEMBL28607133 0.79 CYP19A1 (0.48) CYP19A1SLC6A3MAPTLMNATP53
SCHEMBL28607117 0.79 MAOB (0.44) CYP19A1MAPTLMNATP53CYP1A2
SCHEMBL8117184 0.77 CYP1A2 (0.50) CYP19A1S100A4SLC6A3MAPTLMNA
SCHEMBL28619619 0.77 GPR3 (0.39) MAPTLMNATP53CYP1A2CYP3A4
SCHEMBL28414867 0.76 ESR2 (0.53) CYP19A1SLC6A3RAB9AMAPTLMNA
SCHEMBL28609468 0.76 ALDH1A1 (0.47) CYP19A1RAB9AMAPTLMNATP53
SCHEMBL28611570 0.76 LMNA (0.37) MAPTLMNATP53CYP1A2CYP3A4
SCHEMBL4423401 0.73 ESR2 (0.57) CYP19A1RAB9AMAPTTP53CYP3A4
SCHEMBL15251855 0.72 CYP19A1 (0.43) CYP19A1S100A4CACNB4CACNA1ACACNA1G

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109574818-B Polysubstituted indanone derivative and preparation method thereof 华侨大学 2021-08-03 CN disclosed