Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | EP300 | Q09472 | 1/20 | 0.40 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.40 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.36 |
| ▸ | MYC | P01106 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30827698 | 0.78 | ALOX12 (0.46) | HTTGAAALDH1A1EP300KAT2B | |
| SCHEMBL25528988 | 0.74 | MYC (0.49) | GAAALDH1A1APPHCAR3HCAR2 | |
| SCHEMBL30174245 | 0.74 | MYC (0.49) | GAAALDH1A1APPHCAR3HCAR2 | |
| SCHEMBL4812121 | 0.69 | ALDH1A1 (0.43) | HTTGAAALDH1A1EP300KAT2B | |
| SCHEMBL30977158 | 0.69 | ALDH1A1 (0.51) | HTTGAAALDH1A1EP300KAT2B | |
| SCHEMBL28265682 | 0.68 | MKNK1 (0.48) | ALDH1A1MAPTMKNK1MKNK2 | |
| SCHEMBL19377711 | 0.68 | ALOX12 (0.45) | ALDH1A1ALOX12MAPTRAB9AMDM2 | |
| SCHEMBL22872222 | 0.67 | ALDH1A1 (0.43) | HTTALDH1A1HSD17B10MAPK1L3MBTL1 | |
| SCHEMBL15713999 | 0.66 | EP300 (0.46) | HTTGAAALDH1A1EP300KAT2B | |
| SCHEMBL28624151 | 0.66 | EP300 (0.46) | HTTGAAALDH1A1EP300KAT2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113574055-A | PCSK9 inhibitors and methods of use thereof | 阿斯利康(瑞典)有限公司 | 2021-10-29 | — | — | CN | disclosed |
| CN-113412258-A | PCSK9 inhibitors and methods of use thereof | 阿斯利康(瑞典)有限公司 | 2021-09-17 | — | — | CN | disclosed |