Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EP300 | Q09472 | 1/20 | 0.46 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | MAT2A | P31153 | 4/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28975510 | 0.79 | EP300 (0.46) | EP300KAT2BHTTGAAMAPT | |
| SCHEMBL10059745 | 0.77 | GSK3B (0.45) | EP300KAT2BGAAMAPTMAPK1 | |
| SCHEMBL21065490 | 0.77 | EP300 (0.37) | EP300KAT2BHTTGAAMAPT | |
| SCHEMBL31456689 | 0.76 | ALDH1A1 (0.43) | EP300KAT2BHTTMAPTALDH1A1 | |
| SCHEMBL31456730 | 0.76 | EP300 (0.43) | EP300KAT2BHTTALDH1A1ALOX12 | |
| SCHEMBL21065496 | 0.73 | EP300 (0.41) | EP300KAT2BHTTGAAMAPT | |
| SCHEMBL28620635 | 0.72 | LMNA (0.43) | EP300KAT2BHTTMAPK1ALDH1A1 | |
| SCHEMBL12661004 | 0.72 | EP300 (0.53) | EP300KAT2BHTTGAAMAPT | |
| SCHEMBL16321330 | 0.71 | ALDH1A1 (0.48) | EP300KAT2BHTTALDH1A1MAT2A | |
| SCHEMBL9110239 | 0.71 | HTT (0.55) | EP300KAT2BHTTGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113574055-A | PCSK9 inhibitors and methods of use thereof | 阿斯利康(瑞典)有限公司 | 2021-10-29 | — | — | CN | disclosed |
| CN-113412258-A | PCSK9 inhibitors and methods of use thereof | 阿斯利康(瑞典)有限公司 | 2021-09-17 | — | — | CN | disclosed |