Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terephthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | DAO | P14920 | 1/20 | 0.45 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.45 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
| ▸ | CES1 | P23141 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | TNKS | O95271 | 1/20 | 0.42 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.41 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.41 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.41 |
| ▸ | BAD | Q92934 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | TTR | P02766 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Terephthalic Acid SCHEMBL3979457 | 0.93 | TSHR (0.50) | NPC1RAB9ATSHRDAONAPRT | |
| SCHEMBL5319785 | 0.91 | BCL2L1 (0.50) | NPC1RAB9ATSHRDAONAPRT | |
| Terephthalic Acid SCHEMBL28279901 | 0.89 | TSHR (0.46) | NPC1RAB9ATSHRDAONAPRT | |
| Terephthalic Acid SCHEMBL1234263 | 0.85 | TSHR (0.46) | NPC1RAB9ATSHRDAONAPRT | |
| Terephthalic Acid SCHEMBL28622230 | 0.85 | TSHR (0.46) | NPC1RAB9ATSHRDAONAPRT | |
| SCHEMBL3263009 | 0.84 | RARB (0.50) | TP53KDM4ESMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL8485036 | 0.84 | BCL2L1 (0.47) | NPC1RAB9ATSHRDAONAPRT | |
| Isophthalic Acid SCHEMBL8500503 | 0.83 | KMO (0.49) | EGFRBCL2L1BADKMT2A | |
| Benzoic Acid SCHEMBL5716307 | 0.83 | DAO (0.47) | NPC1RAB9ATSHRDAONAPRT | |
| SCHEMBL9272984 | 0.83 | RARB (0.50) | EGFRBCL2L1BADKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011115580-A1 | A PROCESS FOR MAKING AN ARRAY | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2011-09-22 | — | — | WO | disclosed |