Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | GPR6 | P46095 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14267341 | 0.83 | LMNA (0.52) | NPC1RAB9AMAPTPTGS1PTGS2 | |
| SCHEMBL17141449 | 0.83 | MAPT (0.59) | NPC1RAB9AMAPTPTGS1PTGS2 | |
| SCHEMBL3233511 | 0.81 | SMN1; SMN2 (0.43) | ACHEGPR6NPC1RAB9AMAPT | |
| Hydrochloric Acid SCHEMBL26127692 | 0.81 | MAPT (0.58) | NPC1RAB9AMAPTPTGS1PTGS2 | |
| SCHEMBL25213232 | 0.81 | MAPT (0.43) | ACHENPC1RAB9AMAPTPTGS1 | |
| SCHEMBL3233521 | 0.80 | MAPT (0.45) | ACHEGPR6NPC1RAB9AMAPT | |
| SCHEMBL14539407 | 0.80 | ALDH1A1 (0.44) | ACHEGPR6NPC1RAB9AMAPT | |
| SCHEMBL13990659 | 0.78 | LMNA (0.41) | ACHEGPR6NPC1RAB9AMAPT | |
| SCHEMBL4883305 | 0.77 | MAPT (0.57) | ACHEGPR6NPC1RAB9AMAPT | |
| SCHEMBL24303296 | 0.77 | TRPC3 (0.61) | ACHENPC1RAB9AMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105601617-A | Orthodiazacycle compounds, and preparation method and application thereof | BIOLOGY INST OF SHANDONG ACAD OF SCIENCES | 2016-05-25 | — | — | CN | claimed |
| CN-105601617-B | A kind of neighbour's diazacyclo compound and the preparation method and application thereof | 山东省科学院生物研究所 | 2019-02-22 | — | — | CN | disclosed |
| CN-105601617-A | Orthodiazacycle compounds, and preparation method and application thereof | BIOLOGY INST OF SHANDONG ACAD OF SCIENCES | 2016-05-25 | — | — | CN | disclosed |
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | disclosed |
| US-20080064690-A1 | PYRAZOLE-AMIDES AND -SULFONAMIDES | ICAGEN, INC. (US) | 2008-03-13 | — | — | US | disclosed |
| US-20080064690-A1 | PYRAZOLE-AMIDES AND -SULFONAMIDES | ICAGEN, INC. (US) | 2008-03-13 | — | — | US | disclosed |
| US-20080064690-A1 | PYRAZOLE-AMIDES AND -SULFONAMIDES | ICAGEN, INC. (US) | 2008-03-13 | — | — | US | disclosed |
| US-7223782-B2 | Pyrazole-amides and -sulfonamides | ICAGEN, INC. (US) | 2007-05-29 | — | — | US | disclosed |
| US-7223782-B2 | Pyrazole-amides and -sulfonamides | ICAGEN, INC. (US) | 2007-05-29 | — | — | US | disclosed |
| US-7223782-B2 | Pyrazole-amides and -sulfonamides | ICAGEN, INC. (US) | 2007-05-29 | — | — | US | disclosed |
| EP-1451160-A4 | PYRAZOLE-AMIDES AND-SULFONAMIDES | ICAGEN INC (US) | 2005-04-20 | — | — | EP | disclosed |
| US-20050049237-A1 | Pyrazole-amides and -sulfonamides | ICAGEN, INC. (US) | 2005-03-03 | — | — | US | disclosed |
| EP-1451160-A2 | PYRAZOLE-AMIDES AND-SULFONAMIDES | Icagen, Inc. (US) | 2004-09-01 | — | — | EP | disclosed |
| WO-2003037274-A2 | PYRAZOLE-AMIDES AND-SULFONAMIDES | ICAGEN, INC. (US) | 2003-05-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080064690-A1 | PYRAZOLE-AMIDES AND -SULFONAMIDES | SCN3A, TRPV3, HCN3 | ACHE 595/4885GPR6 3106/4885NPC1 3322/4885 |
| US-20050049237-A1 | Pyrazole-amides and -sulfonamides | SCN3A, TRPV3, HCN3 | ACHE 595/4885GPR6 3106/4885NPC1 3322/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.