Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 2/20 | 0.57 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.53 |
| ▸ | RPS6KB1 | P23443 | 5/20 | 0.48 |
| ▸ | AURKA | O14965 | 3/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 2/20 | 0.46 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.46 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.46 |
| ▸ | TDO2 | P48775 | 1/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.43 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29871030 | 1.00 | APP (0.57) | APPEPHX2RPS6KB1AURKAEGFR | |
| SCHEMBL29870666 | 0.83 | CCNE2 (0.55) | APPRPS6KB1AURKACDK2CCNE2 | |
| SCHEMBL28624481 | 0.83 | CCNE2 (0.55) | APPRPS6KB1AURKACDK2CCNE2 | |
| SCHEMBL28629152 | 0.80 | AURKA (0.46) | RPS6KB1AURKAAURKBKDM4EMAPK1 | |
| SCHEMBL28616350 | 0.80 | APP (0.54) | APPMAPK1MAPK8KMT2A | |
| SCHEMBL28616319 | 0.80 | EPAS1 (0.60) | APPRPS6KB1AURKAEGFRKDM4E | |
| SCHEMBL29870974 | 0.80 | EPAS1 (0.60) | APPRPS6KB1AURKAEGFRKDM4E | |
| SCHEMBL29870643 | 0.80 | AURKA (0.46) | RPS6KB1AURKAAURKBKDM4EMAPK1 | |
| SCHEMBL28623278 | 0.80 | ACHE (0.44) | EGFRCDK2CCNE2CCNE1LMNA | |
| SCHEMBL29870797 | 0.80 | ACHE (0.44) | EGFRCDK2CCNE2CCNE1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113292510-B | Benzisothiazole compound for inhibiting hypoxia inducible factor 2 activity, preparation method and application thereof | 中国药科大学 | 2022-08-26 | — | — | CN | disclosed |
| CN-113292510-A | Benzisothiazole compound for inhibiting hypoxia inducible factor 2 activity, preparation method and application thereof | 中国药科大学 | 2021-08-24 | — | — | CN | disclosed |