Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.41 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.41 |
| ▸ | EP300 | Q09472 | 1/20 | 0.40 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MAT2A | P31153 | 4/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.39 |
| ▸ | TUBB | P07437 | 1/20 | 0.39 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.39 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.39 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.39 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.39 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31456730 | 0.78 | EP300 (0.43) | L3MBTL1CYP11B1CYP11B2EP300KAT2B | |
| SCHEMBL28624151 | 0.72 | EP300 (0.46) | L3MBTL1CYP11B1CYP11B2EP300KAT2B | |
| SCHEMBL31456703 | 0.70 | L3MBTL1 (0.40) | LMNAL3MBTL1CYP11B1CYP11B2ALOX12 | |
| SCHEMBL31456694 | 0.70 | HTR1A (0.41) | CYP11B1CYP11B2EP300KAT2BALOX12 | |
| SCHEMBL30827698 | 0.69 | ALOX12 (0.46) | L3MBTL1EP300KAT2BALOX12ALDH1A1 | |
| SCHEMBL4884791 | 0.67 | CYP2A6 (0.53) | ALOX12ALDH1A1HTTELANE | |
| SCHEMBL28975510 | 0.66 | EP300 (0.46) | L3MBTL1CYP11B2EP300KAT2BALOX12 | |
| SCHEMBL30827652 | 0.66 | CYP11B2 (0.47) | CYP11B1CYP11B2EP300KAT2BALDH1A1 | |
| SCHEMBL22103156 | 0.66 | MAT2A (0.66) | LMNAGFERL3MBTL1MAT2APRMT5 | |
| SCHEMBL15839005 | 0.66 | SLC2A1 (0.44) | LMNAGFERL3MBTL1CYP19A1CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113574055-A | PCSK9 inhibitors and methods of use thereof | 阿斯利康(瑞典)有限公司 | 2021-10-29 | — | — | CN | disclosed |
| CN-113412258-A | PCSK9 inhibitors and methods of use thereof | 阿斯利康(瑞典)有限公司 | 2021-09-17 | — | — | CN | disclosed |