SCHEMBL28627352

SCHEMBL28627352

S=C(CBr)c1ccc(Cl)cc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GSK3B P49841 2/20 0.56
ALDH1A1 P00352 5/20 0.43
HPGD P15428 4/20 0.43
MAPT P10636 3/20 0.43
DUSP3 P51452 1/20 0.43
PTPN5 P54829 1/20 0.43
PTPN11 Q06124 1/20 0.43
APOBEC3G Q9HC16 1/20 0.43
NPC1 O15118 1/20 0.43
HTT P42858 1/20 0.43
RAB9A P51151 1/20 0.43
NPSR1 Q6W5P4 1/20 0.43
TSHR P16473 3/20 0.42
HSD17B10 Q99714 2/20 0.42
PHGDH O43175 1/20 0.42
MGLL Q99685 1/20 0.42
CES2 O00748 1/20 0.42
CES1 P23141 1/20 0.42
L3MBTL1 Q9Y468 2/20 0.41
ALOX15 P16050 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7841592 0.76 ALDH1A1 (0.47) GSK3BALDH1A1HPGDMAPTDUSP3
SCHEMBL5312640 0.76 GSK3B (0.56) GSK3BALDH1A1HPGDMAPTNPC1
SCHEMBL10722261 0.75 GSK3B (0.52) GSK3BALDH1A1HPGDMAPTTSHR
SCHEMBL1039390 0.73 PTPN1 (0.59) GSK3BALDH1A1HPGDMAPTNPC1
SCHEMBL118608 0.71 GSK3B (1.00) GSK3BMAPTNPC1RAB9ATSHR
SCHEMBL991358 0.71 GSK3B (0.56) GSK3BALDH1A1MAPTTSHRCES2
SCHEMBL11806224 0.71 GAA (0.43) ALDH1A1HPGDMAPTDUSP3PTPN5
SCHEMBL10316095 0.71 GSK3B (0.60) GSK3BALDH1A1MAPTCA1CA2
SCHEMBL29068168 0.70 CA1 (0.58) GSK3BALDH1A1HPGDMAPTNPC1
SCHEMBL4066365 0.70 MAPT (0.61) ALDH1A1HPGDMAPTNPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113402556-A Compound and application thereof 北京鼎材科技有限公司 2021-09-17 CN disclosed