Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Thiosemicarbazide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA known ✓ | P21397 | 1/20 | 0.33 |
| ▸ | MAOB known ✓ | P27338 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.56 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | BLM | P54132 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | CA5A | P35218 | 2/20 | 0.33 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | THPO | P40225 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TAS2R38 | P59533 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pimagedine SCHEMBL27731082 | 0.92 | ALDH1A1 (0.53) | ALDH1A1HSD17B10PTGS2KDM4EBLM | |
| Thiosemicarbazide SCHEMBL7524661 | 0.91 | ALDH1A1 (0.67) | ALDH1A1HSD17B10PTGS2KDM4EBLM | |
| Thiosemicarbazide SCHEMBL11687122 | 0.88 | ALDH1A1 (0.62) | ALDH1A1HSD17B10PTGS2KDM4EBLM | |
| Thiosemicarbazide SCHEMBL11685737 | 0.85 | — | — | |
| Sulfuric Acid SCHEMBL10539875 | 0.82 | KDM4E (0.50) | KDM4EBLMCYP2D6CYP2C19NPSR1 | |
| Pimagedine SCHEMBL27731079 | 0.81 | BLM (0.63) | ALDH1A1HSD17B10PTGS2KDM4EBLM | |
| Pimagedine SCHEMBL439903 | 0.79 | KDM4E (0.48) | ALDH1A1HSD17B10PTGS2KDM4EBLM | |
| Pimagedine SCHEMBL728583 | 0.79 | KDM4E (0.48) | ALDH1A1HSD17B10PTGS2KDM4EBLM | |
| Thiosemicarbazide SCHEMBL28824583 | 0.79 | ALDH1A1 (0.50) | ALDH1A1HSD17B10PTGS2TSHRCYP1A2 | |
| Sulfuric Acid SCHEMBL1318239 | 0.78 | BLM (0.59) | ALDH1A1HSD17B10KDM4EBLMCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113463074-B | Copper deposition composition and copper deposition method | 广东硕成科技股份有限公司 | 2022-06-14 | — | — | CN | disclosed |
| CN-113463074-A | Copper deposition composition and copper deposition method | 广东硕成科技有限公司 | 2021-10-01 | — | — | CN | disclosed |