Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3CALCRLCHRM1CHRM2CHRM3F2RMAOAMAOBMAP2K1MAP2K2NTRK1NTRK2NTRK3OPRD1OPRK1OPRM1P2RY12PKLRSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASLC18A2SLC6A2SLC6A3TLR7TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8dacAdacBdacCfolAftsImrcAmrcBmrdApolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmB1rpmB2rpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmHrpmIrpmJrpmJ2rpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsR1rpsR2rpsSrpsTrpsUrpsZykgMykgO
The experimentally established mechanism targets of Pimagedine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA known ✓ | P21397 | 1/20 | 0.39 |
| ▸ | MAOB known ✓ | P27338 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | BLM | P54132 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | CA5A | P35218 | 2/20 | 0.40 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | THPO | P40225 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 2/20 | 0.35 |
| ▸ | NT5E | P21589 | 1/20 | 0.35 |
| ▸ | CA4 | P22748 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pimagedine SCHEMBL728583 | 1.00 | KDM4E (0.48) | KDM4EBLMCYP2D6CYP2C19NPSR1 | |
| Pimagedine SCHEMBL28939705 | 0.97 | KDM4E (0.46) | KDM4EBLMCYP2D6CYP2C19NPSR1 | |
| Pimagedine SCHEMBL9702626 | 0.97 | KDM4E (0.46) | KDM4EBLMCYP2D6CYP2C19NPSR1 | |
| Pimagedine SCHEMBL4259785 | 0.90 | KDM4E (0.46) | KDM4EBLMCYP2D6CYP2C19NPSR1 | |
| Pimagedine SCHEMBL4821332 | 0.90 | KDM4E (0.46) | KDM4EBLMCYP2D6CYP2C19NPSR1 | |
| Pimagedine SCHEMBL9797617 | 0.90 | TSHR (0.50) | KDM4EBLMCYP2D6CYP2C19NPSR1 | |
| Pimagedine SCHEMBL27731082 | 0.89 | ALDH1A1 (0.53) | KDM4EBLMCYP2D6CYP2C19NPSR1 | |
| Pimagedine SCHEMBL30862143 | 0.83 | LMNA (0.43) | KDM4EBLMCYP2D6CYP2C19NPSR1 | |
| Pimagedine SCHEMBL30862137 | 0.83 | CYP2C19 (0.40) | KDM4EBLMCYP2D6CYP2C19NPSR1 | |
| Pimagedine SCHEMBL7763659 | 0.82 | ALDH1A1 (0.43) | TSHRCYP1A2NFKB1MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 624 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4640204-A2 | HAIR COSMETIC COMPOSITION | Kao Corporation (JP) | 2025-10-29 | — | — | EP | claimed |
| EP-3831362-B1 | HAIR COSMETIC COMPOSITION | KAO CORP (JP) | 2025-10-15 | — | — | EP | claimed |
| CN-120136744-A | Novel intermediate of 5-cyanoindole and preparation method thereof | 台州职业技术学院 | 2025-06-13 | — | — | CN | claimed |
| CN-119753848-A | Amino guanidine oxalate second-order nonlinear optical crystal material, preparation and application thereof | 同济大学 | 2025-04-04 | — | — | CN | claimed |
| CN-119332364-A | Antibacterial deodorizing fabric and preparation process thereof | 罗莱生活科技股份有限公司 | 2025-01-21 | — | — | CN | claimed |
| CN-119332363-A | Deodorizing fiber, deodorizing fabric and preparation process of deodorizing fiber and deodorizing fabric | 罗莱生活科技股份有限公司 | 2025-01-21 | — | — | CN | claimed |
| WO-2025000625-A1 | CHEMICAL COOLANT AND USE THEREOF IN AEROSOL-BASED FIRE EXTINGUISHING | 湖北及安盾消防科技有限公司 | 2025-01-02 | — | — | WO | claimed |
| CN-118930459-A | Lead compound of targeted human lipocalin 2 or pharmaceutically acceptable salt thereof, and preparation method and application thereof | 中国科学技术大学 | 2024-11-12 | — | — | CN | claimed |
| CN-118754829-A | Energetic salt containing multiple dinitramide anions, preparation method thereof and solid propellant energetic oxidant | 湖北航天化学技术研究所 | 2024-10-11 | — | — | CN | claimed |
| US-12042777-B2 | Deodorant composition suitable for aldehyde-based gas or ketone-based gas | TOAGOSEI CO., LTD. (JP) | 2024-07-23 | — | — | US | claimed |
| US-20020115724-A1 | Methods and agents for inhibiting protein aging | CERAMI ANTHONY (US) | 2002-08-22 | — | — | US | claimed |
| EP-0669325-B1 | Process for producing 5-amino-tetrazole | NIPPON CARBIDE KOGYO KK (JP) | 2002-06-05 | — | — | EP | claimed |
| EP-1093422-A2 | PYROTECHNIC GAS GENERANT COMPOSITION INCLUDING HIGH OXYGEN BALANCE FUEL | ATLANTIC RESEARCH CORPORATION (US) | 2001-04-25 | — | — | EP | claimed |
| CN-1282775-A | chemical mechanical polishing composition and method | CHANGXING CHEMICAL INDUSTRY CO (CN) | 2001-02-07 | — | — | CN | claimed |
| US-6114323-A | DIABETIC KIDNEY DISEASE; ADMINISTERING AMINOGUANIDINE | THE ROCKEFELLER UNIVERSITY (US) | 2000-09-05 | — | — | US | claimed |
| WO-2000000365-A9 | PYROTECHNIC GAS GENERANT COMPOSITION INCLUDING HIGH OXYGEN BALANCE FUEL | ATLANTIC RES CORP (US) | 2000-06-08 | — | — | WO | claimed |
| WO-2000000365-A2 | PYROTECHNIC GAS GENERANT COMPOSITION INCLUDING HIGH OXYGEN BALANCE FUEL | ATLANTIC RESEARCH CORPORATION (US) | 2000-01-06 | — | — | WO | claimed |
| US-5852009-A | Compositions, including pharmaceutical compositions, for inhibiting the advanced glycosylation of proteins, and therapeutic methods based thereon | THE ROCKEFELLER UNIVERSITY (US) | 1998-12-22 | — | — | US | claimed |
| US-5559243-A | Processes for producing a salt of N-guanidino thiourea and 3-amino-5-mercapto-1,2,4-triazole | NIPPON CARBIDE KOGYO KABUSHIKI KAISHA (JP) | 1996-09-24 | — | — | US | claimed |
| US-5128360-A | Inhibition of advanced glycosylation end products of target proteins using aminoguanidine and-or hydrazinohistidine | THE ROCKEFELLER UNIVERSITY (US) | 1992-07-07 | — | — | US | claimed |