Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK1 | Q13153 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 2/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | ACKR3 | P25106 | 3/20 | 0.36 |
| ▸ | AKT1 | P31749 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL973571 | 0.85 | HRH3 (0.37) | PAK1BTKHRH3ACKR3AKT1 | |
| SCHEMBL2861257 | 0.85 | SMN1; SMN2 (0.37) | PAK1BTKACKR3MEN1KMT2A | |
| SCHEMBL2856320 | 0.84 | CHRNA7 (0.40) | PAK1BTKHRH3ACKR3KMT2A | |
| SCHEMBL973764 | 0.83 | BTK (0.45) | BTKHRH3ACKR3AKT1CHRNA7 | |
| SCHEMBL2862996 | 0.83 | CCNE1 (0.38) | BTKHRH3ACKR3MEN1KMT2A | |
| SCHEMBL2855060 | 0.83 | ALDH1A1 (0.43) | PAK1BTKHRH3ACKR3MEN1 | |
| SCHEMBL972148 | 0.81 | GRM5 (0.39) | BTKHRH3ACKR3MEN1KMT2A | |
| SCHEMBL975872 | 0.80 | CA12 (0.41) | BTKHRH3ACKR3CHRNA7ALDH1A1 | |
| SCHEMBL2854730 | 0.80 | CTSB (0.37) | PAK1BTKACKR3MEN1KMT2A | |
| SCHEMBL974821 | 0.79 | HRH3 (0.38) | PAK1BTKHRH3ACKR3CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968957-B1 | SUBSTITUTED THIAZOLES AND THEIR USE FOR PRODUCING DRUGS | GRUENENTHAL GMBH (DE) | 2010-01-20 | — | — | EP | claimed |