Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARD | Q03181 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.36 |
| ▸ | CDK2 | P24941 | 4/20 | 0.36 |
| ▸ | BTK | Q06187 | 4/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.35 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.34 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2858043 | 0.89 | CCNE1 (0.40) | PPARGPPARDPPARACCNE1CDK2 | |
| SCHEMBL974290 | 0.87 | BTK (0.38) | PPARGPPARDPPARABTKSMPD3 | |
| SCHEMBL2854222 | 0.86 | SMN1; SMN2 (0.40) | CCNE1CDK2BTKPOLBMAPT | |
| SCHEMBL2861257 | 0.84 | SMN1; SMN2 (0.37) | CCNE1CDK2BTKPOLBSMPD3 | |
| SCHEMBL2856320 | 0.84 | CHRNA7 (0.40) | CCNE1CDK2BTKSMPD3PAK1 | |
| SCHEMBL2853786 | 0.83 | LMNA (0.38) | BTKPOLBMAPTPAK1CTSB | |
| SCHEMBL973992 | 0.81 | BTK (0.45) | PPARDPPARABTKSMPD3NPC1 | |
| SCHEMBL972939 | 0.80 | BTK (0.38) | PPARGPPARDPPARACCNE1CDK2 | |
| SCHEMBL974372 | 0.79 | SMPD3 (0.36) | PPARDPPARABTKSMPD3NPC1 | |
| SCHEMBL972757 | 0.79 | SMPD3 (0.41) | PPARDPPARACCNE1CDK2BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968957-B1 | SUBSTITUTED THIAZOLES AND THEIR USE FOR PRODUCING DRUGS | GRUENENTHAL GMBH (DE) | 2010-01-20 | — | — | EP | claimed |