Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Fluocinonide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 5/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 10/20 | 0.58 |
| ▸ | LMNA | P02545 | 7/20 | 0.58 |
| ▸ | PGR | P06401 | 5/20 | 0.58 |
| ▸ | AR | P10275 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | CNR1 | P21554 | 2/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fluocinonide SCHEMBL28122375 | 0.88 | HIF1A (0.75) | HIF1ALMNANR3C1PGRAR | |
| Fluocinonide SCHEMBL3475945 | 0.88 | HIF1A (0.75) | HIF1ALMNANR3C1PGRAR | |
| Betamethasone SCHEMBL3224067 | 0.85 | NR3C1 (0.68) | HIF1ALMNANR3C1PGRAR | |
| Dexamethasone SCHEMBL3135309 | 0.85 | NR3C1 (0.68) | HIF1ALMNANR3C1PGRAR | |
| Fluocinolone Acetonide SCHEMBL5501859 | 0.83 | HIF1A (0.77) | HIF1ALMNANR3C1PGRAR | |
| Fluocinonide SCHEMBL11325670 | 0.82 | HIF1A (0.82) | HIF1ALMNANR3C1PGRAR | |
| Fluocinonide SCHEMBL5664031 | 0.82 | NR3C1 (0.62) | HIF1ALMNANR3C1PGRAR | |
| Amcinonide SCHEMBL2864339 | 0.81 | HIF1A (0.74) | HIF1ALMNANR3C1PGRAR | |
| Betamethasone Acetate SCHEMBL3882689 | 0.81 | HIF1A (0.71) | HIF1ALMNANR3C1PGRAR | |
| Fluocinonide SCHEMBL15568196 | 0.80 | HIF1A (0.58) | HIF1ALMNANR3C1PGRAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2253339-B1 | A process for producing stents and corresponding stent | SORIN BIOMEDICA CARDIO SRL (IT) | 2011-12-28 | — | — | EP | disclosed |
| US-8084076-B2 | Process for producing stents and corresponding stents | SORIN BIOMEDICA CARDIO S.R.L. (IT) | 2011-12-27 | — | — | US | disclosed |
| EP-2253339-A1 | A process for producing stents and corresponding stent | Sorin Biomedica Cardio S.r.l. (IT) | 2010-11-24 | — | — | EP | disclosed |
| EP-1449546-B1 | A process for producing stents and corresponding stent | SORIN BIOMEDICA CARDIO SRL (IT) | 2010-10-27 | — | — | EP | disclosed |
| US-20080140186-A1 | PROCESS FOR PRODUCING STENTS AND CORRESPONDING STENTS | SORIN BIOMEDICA CARDIO S.R.L. (IT) | 2008-06-12 | — | — | US | disclosed |
| US-20040167612-A1 | Process for producing stents and corresponding stents | SORIN BIOMEDICA CARDIO S.R.L. (IT) | 2004-08-26 | — | — | US | disclosed |
| EP-1449546-A1 | A process for producing stents and corresponding stent | SORIN BIOMEDICA S.p.A. (IT) | 2004-08-25 | — | — | EP | disclosed |