Fluocinonide

SCHEMBL15568196

CC(=O)OCC(=O)[C@@]12OC(C)(C)O[C@@H]1C[C@H]1[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]12C.CC1(C)O[C@@H]2C[C@H]3[C@@H]4C[C@H](F)C5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]3(C)[C@]2(C(=O)CO)O1.CCCC(=O)O[C@]1(C(=O)CO)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3[C@@H](O)C[C@@]21C.C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2[C@@H](O)C[C@@]2(C)[C@H]1CC[C@]2(O)C(=O)CO

nearest known ligand 0.58

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

NR3C1

The experimentally established mechanism targets of Fluocinonide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	NR3C1 known ✓	P04150	5/20	0.58

▸	HIF1A	Q16665	8/20	0.58

▸	LMNA	P02545	8/20	0.58

▸	PGR	P06401	7/20	0.58

▸	AR	P10275	4/20	0.58

▸	KMT2A	Q03164	2/20	0.58

▸	ALDH1A1	P00352	1/20	0.58

▸	MEN1	O00255	1/20	0.58

▸	NPSR1	Q6W5P4	2/20	0.57

▸	NR3C2	P08235	4/20	0.53

▸	CYP3A4	P08684	3/20	0.53

▸	MAPT	P10636	2/20	0.53

▸	HSD17B10	Q99714	1/20	0.53

▸	TDP1	Q9NUW8	1/20	0.53

▸	KDM4E	B2RXH2	1/20	0.53

▸	MAPK1	P28482	1/20	0.53

▸	CHRM1	P11229	2/20	0.50

▸	SERPINA6	P08185	1/20	0.48

▸	CNR1	P21554	1/20	0.47

▸	KCNH2	Q12809	1/20	0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Fluocinolone Acetonide SCHEMBL15568127	0.96	HIF1A (0.57)	HIF1ALMNAPGRNR3C1AR
Fluocinonide SCHEMBL5664031	0.90	NR3C1 (0.62)	HIF1ALMNAPGRNR3C1AR
Difluprednate SCHEMBL20270247	0.89	HIF1A (0.72)	HIF1ALMNAPGRNR3C1AR
Difluprednate SCHEMBL4959751	0.87	LMNA (0.66)	HIF1ALMNAPGRNR3C1AR
Fluocinolone Acetonide SCHEMBL8451856	0.83	NR3C1 (0.60)	HIF1ALMNAPGRNR3C1AR
Fluocinonide SCHEMBL616754	0.81	NR3C1 (0.74)	HIF1ALMNAPGRNR3C1AR
Prednicarbate SCHEMBL6470591	0.81	NR3C1 (0.57)	HIF1ALMNAPGRNR3C1AR
Fluocinonide SCHEMBL2863286	0.80	HIF1A (0.58)	HIF1ALMNAPGRNR3C1AR
Hydrocortisone Butyrate SCHEMBL1535101	0.79	NR3C2 (0.82)	HIF1ALMNAPGRNR3C1AR
Fluocinonide SCHEMBL8425065	0.79	HIF1A (0.64)	HIF1ALMNAPGRNR3C1AR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2014027006-A1	BIOADHESIVE FORMULATIONS FOR USE IN DRUG DELIVERY	EDKO PAZARLAMA TANITIM TICARET LIMITED SIRKETI (TR)	2014-02-20	—	—	WO	disclosed