SCHEMBL28633296

SCHEMBL28633296

O=C(NCCc1ccc(O)cc1)c1cc(Cl)nnc1Cl

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 3/20 0.55
RAB9A P51151 3/20 0.55
MAPT P10636 2/20 0.55
CYP1A2 P05177 1/20 0.55
GAA P10253 1/20 0.55
CYP2D6 P10635 1/20 0.55
CYP2C19 P33261 1/20 0.55
GFER P55789 1/20 0.55
SMN1; SMN2 Q16637 1/20 0.55
DNMT3A Q9Y6K1 1/20 0.54
ESRRG P62508 5/20 0.51
ESRRB O95718 4/20 0.51
AKR1B10 O60218 1/20 0.49
AKR1B1 P15121 1/20 0.49
MT-CO2 P00403 1/20 0.48
KDM4E B2RXH2 1/20 0.48
F13A1 P00488 1/20 0.48
SYK P43405 2/20 0.46
LMNA P02545 2/20 0.46
KMT2A Q03164 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31622388 0.90 MAPT (0.57) NPC1RAB9AMAPTCYP1A2GAA
SCHEMBL31683863 0.88 NPC1 (0.49) NPC1RAB9AMAPTGAASMN1; SMN2
SCHEMBL28635932 0.88 NPC1 (0.49) NPC1RAB9AMAPTGAASMN1; SMN2
SCHEMBL7703547 0.88 RAB9A (0.61) NPC1RAB9AMAPTSMN1; SMN2KDM4E
SCHEMBL31683856 0.88 RAB9A (0.61) NPC1RAB9AMAPTSMN1; SMN2KDM4E
SCHEMBL28628718 0.85 KMT2A (0.64) CYP1A2GAACYP2D6CYP2C19SMN1; SMN2
SCHEMBL31683865 0.85 KMT2A (0.64) CYP1A2GAACYP2D6CYP2C19SMN1; SMN2
SCHEMBL28631718 0.82 SMN1; SMN2 (0.58) NPC1RAB9AMAPTGAASMN1; SMN2
SCHEMBL31683858 0.82 SMN1; SMN2 (0.58) NPC1RAB9AMAPTGAASMN1; SMN2
SCHEMBL31683855 0.81 ALDH1A1 (0.40) NPC1RAB9AMAPTSMN1; SMN2AKR1B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113490663-A Pyridazine (thio) amides as fungicidal compounds 拜耳公司 2021-10-08 CN disclosed