Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.50 |
| ▸ | PDE10A | Q9Y233 | 7/20 | 0.39 |
| ▸ | PDE2A | O00408 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.37 |
| ▸ | CYP2B6 | P20813 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.37 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.37 |
| ▸ | CTSA | P10619 | 1/20 | 0.36 |
| ▸ | PDE5A | O76074 | 2/20 | 0.36 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.36 |
| ▸ | TDO2 | P48775 | 1/20 | 0.36 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11620293 | 0.72 | ALDH1A1 (0.46) | CHEK1MAPTPDGFRB | |
| SCHEMBL30443819 | 0.70 | TLR8 (0.43) | PDE10AMAPTCYP3A4CYP2C19PDGFRB | |
| SCHEMBL22418950 | 0.69 | ALDH1A1 (0.67) | PDE10APDE2AMAPTCYP3A4PDGFRB | |
| SCHEMBL4655563 | 0.69 | MEN1 (0.55) | CHEK1PDE10APDE2AMAPTCYP3A4 | |
| SCHEMBL21241506 | 0.69 | PDE10A (0.43) | CHEK1PDE10APDE2AMAPTPDGFRB | |
| SCHEMBL20000896 | 0.68 | HSD17B1 (0.50) | CYP2A6CYP2B6CYP3A4CYP2C19 | |
| SCHEMBL26104326 | 0.67 | CYP2A6 (0.64) | MAPTCYP2A6CYP2B6CYP3A4CYP2C19 | |
| SCHEMBL8431291 | 0.66 | PDGFRB (0.38) | MAPTPDGFRBKIT | |
| SCHEMBL4735387 | 0.65 | ERN1 (0.51) | PDE10APDE2AMAPTPDGFRBPDGFRA | |
| SCHEMBL30279632 | 0.65 | AKT2 (0.50) | CHEK1MAPTCYP2A6CYP2B6CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113490666-A | Substituted pyrazolo [1,5-A ] pyridine compounds as inhibitors of FGFR tyrosine kinases | 奥瑞生物药品公司 | 2021-10-08 | — | — | CN | disclosed |