Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 5/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | GPR183 | P32249 | 1/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28627469 | 0.87 | SLC6A19 (0.53) | MCHR1RAB9AKDM4EHDAC1HDAC8 | |
| SCHEMBL28887209 | 0.86 | ALDH1A1 (0.42) | LMNARAB9AKDM4EGPR183HDAC1 | |
| SCHEMBL28887208 | 0.86 | ALDH1A1 (0.42) | LMNARAB9AKDM4EGPR183HDAC1 | |
| SCHEMBL28456104 | 0.82 | SAE1 (0.45) | LMNARAB9AKDM4EHDAC1HDAC8 | |
| SCHEMBL30632573 | 0.82 | MEN1 (0.52) | RAB9AKDM4ESMN1; SMN2NPSR1MAPT | |
| SCHEMBL28515989 | 0.81 | NPC1 (0.48) | LMNARAB9AKDM4EHDAC1SMN1; SMN2 | |
| SCHEMBL30035914 | 0.81 | NPC1 (0.48) | LMNARAB9AKDM4EHDAC1SMN1; SMN2 | |
| SCHEMBL28372132 | 0.80 | MAPT (0.39) | LMNARAB9AKDM4EHDAC1SMN1; SMN2 | |
| SCHEMBL30035241 | 0.79 | VCP (0.38) | LMNARAB9AHDAC1SMN1; SMN2NPSR1 | |
| SCHEMBL28528919 | 0.79 | HDAC1 (0.36) | LMNARAB9AKDM4EHDAC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111072663-B | 8-substituted styrylxanthine derivatives and uses thereof | 广东东阳光药业有限公司 | 2021-10-01 | — | — | CN | disclosed |
| CN-111072663-A | 8-substituted styrylxanthine derivatives and uses thereof | 广东东阳光药业有限公司 | 2020-04-28 | — | — | CN | disclosed |