Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.47 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.40 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.39 |
| ▸ | NNMT | P40261 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.37 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL856809 | 0.85 | BAZ2B (0.56) | HDAC6HDAC1BAZ2BGRM5HDAC2 | |
| SCHEMBL6517705 | 0.81 | HDAC1 (0.46) | HDAC6HDAC1KDM4EHCAR3 | |
| SCHEMBL22230063 | 0.79 | FDFT1 (0.33) | HDAC6HDAC1HCAR3FDFT1NNMT | |
| SCHEMBL958814 | 0.77 | HDAC1 (0.46) | HDAC6HDAC1GAAP4HTM | |
| SCHEMBL17982190 | 0.76 | P4HTM (0.65) | HDAC6HDAC1P4HTM | |
| SCHEMBL11791404 | 0.76 | ALDH1A1 (0.61) | HDAC6HDAC1KDM4EGAAALDH1A1 | |
| SCHEMBL17796689 | 0.76 | GABRA5 (0.46) | HDAC6HDAC1KDM4E | |
| SCHEMBL1462224 | 0.76 | MLYCD (0.56) | HDAC6HDAC1KDM4E | |
| SCHEMBL22384226 | 0.75 | HDAC1 (0.59) | HDAC6HDAC1KDM4EGAAALDH1A1 | |
| SCHEMBL29480657 | 0.75 | KCNJ1 (0.46) | HDAC6HDAC1HCAR3NNMTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113574055-A | PCSK9 inhibitors and methods of use thereof | 阿斯利康(瑞典)有限公司 | 2021-10-29 | — | — | CN | disclosed |
| CN-113412258-A | PCSK9 inhibitors and methods of use thereof | 阿斯利康(瑞典)有限公司 | 2021-09-17 | — | — | CN | disclosed |