Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.46 |
| ▸ | HPGDS | O60760 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.43 |
| ▸ | CDK8 | P49336 | 1/20 | 0.43 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17796689 | 0.81 | GABRA5 (0.46) | HDAC1HDAC6KDM4EGABRA5 | |
| SCHEMBL1462224 | 0.81 | MLYCD (0.56) | HDAC1HDAC6KDM4E | |
| SCHEMBL9561524 | 0.81 | ALDH1A1 (0.51) | HPGDSKDM4E | |
| SCHEMBL5431621 | 0.81 | KDM4E (0.67) | HDAC1HDAC6HPGDSKDM4EGABRA1 | |
| SCHEMBL28634841 | 0.81 | HDAC6 (0.47) | HDAC1HDAC6KDM4EHCAR3 | |
| SCHEMBL856809 | 0.80 | BAZ2B (0.56) | HDAC1HDAC6HPGDS | |
| SCHEMBL3298763 | 0.80 | ALDH1A1 (0.56) | HDAC1HDAC6KDM4E | |
| SCHEMBL22692894 | 0.79 | HPGDS (0.46) | HDAC1HDAC6HPGDSKDM4EHCAR3 | |
| SCHEMBL11982165 | 0.79 | HDAC1 (0.64) | HDAC1HDAC6HPGDSKDM4EGABRA1 | |
| SCHEMBL4395941 | 0.79 | L3MBTL1 (0.63) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593102-B1 | OXAZOLE DERIVATIVES USEFUL AS MODULATORS OF FAAH | MERCK SHARP & DOHME (US) | 2017-06-07 | — | — | EP | disclosed |
| US-9073879-B2 | Oxazole derivatives useful as modulators of FAAH | MERCK SHARP & DOHME CORP. (US) | 2015-07-07 | — | — | US | disclosed |
| US-20130012526-A1 | OXAZOLE DERIVATIVES USEFUL AS MODULATORS OF FAAH | MERCK SHARP & DOHME CORP. (US) | 2013-01-10 | — | — | US | disclosed |
| US-20110059942-A1 | Azetidinyl G-Protein Coupled Receptor Agonists | PROSIDION LIMITED (GB) | 2011-03-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110059942-A1 | Azetidinyl G-Protein Coupled Receptor Agonists | GPR119, GIPR, GPR39 | HDAC1 3720/4885HDAC6 4111/4885HPGDS 588/4885 |
| US-20130012526-A1 | OXAZOLE DERIVATIVES USEFUL AS MODULATORS OF FAAH | FAAH, FAAH2, ALOX5 | HDAC1 804/4885HDAC6 833/4885HPGDS 319/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.