Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.65 |
| ▸ | MEN1 | O00255 | 4/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.65 |
| ▸ | HPGD | P15428 | 1/20 | 0.65 |
| ▸ | TP53 | P04637 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.47 |
| ▸ | BRD4 | O60885 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.44 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SPR | P35270 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28621975 | 0.88 | MEN1 (0.51) | KMT2AMEN1KDM4EHPGDTP53 | |
| SCHEMBL28621885 | 0.88 | MEN1 (0.51) | KMT2AMEN1KDM4EHPGDTP53 | |
| SCHEMBL28629849 | 0.87 | KMT2A (0.49) | KMT2AMEN1KDM4EHPGDMAPT | |
| SCHEMBL29160657 | 0.83 | NPC1 (0.53) | KMT2AMEN1KDM4EHPGDTP53 | |
| SCHEMBL28627007 | 0.82 | SPR (0.48) | KMT2AMEN1KDM4EHPGDTP53 | |
| SCHEMBL28629852 | 0.81 | SPR (0.50) | KMT2AMEN1KDM4EHPGDTP53 | |
| SCHEMBL28631064 | 0.79 | ALDH1A1 (0.55) | KMT2AMEN1HPGDMAPTLMNA | |
| SCHEMBL20120108 | 0.78 | KDM4E (0.50) | KMT2AMEN1KDM4EHPGDTP53 | |
| SCHEMBL29123527 | 0.78 | PLA2G2A (0.46) | KMT2AMEN1KDM4EHPGDTP53 | |
| SCHEMBL28621882 | 0.77 | SPR (0.51) | KMT2AMEN1KDM4EHPGDTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113429332-B | 3-substituted indole derivative, preparation method thereof and application thereof in antitumor drugs | 长春工业大学 | 2023-12-15 | — | — | CN | disclosed |
| CN-113429332-A | 3-substituted indole derivative, preparation method thereof and application thereof in antitumor drugs | 长春工业大学 | 2021-09-24 | — | — | CN | disclosed |