SCHEMBL28635375

SCHEMBL28635375

ON=C(NCc1ccc(F)cc1)c1ccccc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PLA2G1B P04054 2/20 0.56
ATG4B Q9Y4P1 2/20 0.56
ALDH1A1 P00352 5/20 0.52
KMT2A Q03164 3/20 0.52
LMNA P02545 3/20 0.52
MEN1 O00255 2/20 0.52
ALOX12 P18054 1/20 0.52
RECQL P46063 1/20 0.52
RAB9A P51151 2/20 0.51
KDM4E B2RXH2 2/20 0.51
HPGD P15428 1/20 0.51
MAOB P27338 2/20 0.50
NPC1 O15118 1/20 0.50
POLB P06746 1/20 0.50
CYP1A2 P05177 1/20 0.49
CYP2C19 P33261 1/20 0.49
THRB P10828 1/20 0.47
NPSR1 Q6W5P4 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
HTT P42858 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28635373 1.00 PLA2G1B (0.56) PLA2G1BATG4BALDH1A1KMT2ALMNA
SCHEMBL28646790 0.93 PLA2G1B (0.56) PLA2G1BATG4BALDH1A1KMT2ALMNA
SCHEMBL28646793 0.93 PLA2G1B (0.56) PLA2G1BATG4BALDH1A1KMT2ALMNA
SCHEMBL28635370 0.88 ALOX12 (0.50) ALDH1A1KMT2ALMNAMEN1ALOX12
SCHEMBL28635369 0.88 ALOX12 (0.50) ALDH1A1KMT2ALMNAMEN1ALOX12
SCHEMBL28632720 0.83 SMN1; SMN2 (0.56) ALDH1A1KMT2ALMNAMEN1RAB9A
SCHEMBL28632717 0.83 SMN1; SMN2 (0.56) ALDH1A1KMT2ALMNAMEN1RAB9A
SCHEMBL28640297 0.83 ALDH1A1 (0.51) ALDH1A1KMT2ALMNAMEN1ALOX12
SCHEMBL28640295 0.83 ALDH1A1 (0.51) ALDH1A1KMT2ALMNAMEN1ALOX12
SCHEMBL28644082 0.77 VNN1 (0.44) KMT2ALMNAMEN1HPGDPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113502491-A Electrochemical preparation method of Tioxazafen and atrareum intermediate 湖南大学 2021-10-15 CN disclosed