Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Fluorouracil. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | THPO | P40225 | 1/20 | 0.59 |
| ▸ | MTOR | P42345 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | HBB | P68871 | 1/20 | 0.59 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fluorouracil SCHEMBL28206325 | 0.83 | LMNA (0.68) | LMNAALDH1A1SMN1; SMN2MAPTCYP19A1 | |
| Fluorouracil SCHEMBL20775915 | 0.82 | LMNA (0.70) | LMNAALDH1A1SMN1; SMN2MAPTCYP19A1 | |
| Fluorouracil SCHEMBL27747751 | 0.81 | LMNA (0.76) | LMNAALDH1A1SMN1; SMN2MAPTCYP19A1 | |
| Fluorouracil SCHEMBL30516153 | 0.81 | LMNA (0.63) | LMNAALDH1A1SMN1; SMN2MAPTCYP19A1 | |
| Fluorouracil SCHEMBL21570798 | 0.79 | LMNA (0.61) | LMNAALDH1A1SMN1; SMN2MAPTCYP19A1 | |
| Fluorouracil SCHEMBL10004716 | 0.79 | LMNA (0.61) | LMNAALDH1A1SMN1; SMN2MAPTCYP19A1 | |
| Fluorouracil SCHEMBL27927726 | 0.79 | LMNA (0.86) | LMNAALDH1A1SMN1; SMN2MAPTCYP19A1 | |
| Adipic Acid SCHEMBL28687655 | 0.79 | LMNA (0.66) | LMNAALDH1A1SMN1; SMN2MAPTCYP19A1 | |
| Fluorouracil SCHEMBL21525858 | 0.78 | LMNA (0.76) | LMNAALDH1A1SMN1; SMN2MAPTCYP19A1 | |
| Fluorouracil SCHEMBL28194757 | 0.78 | LMNA (0.76) | LMNAALDH1A1SMN1; SMN2MAPTCYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116640096-A | 5-fluorouracil-sarcosine eutectic crystal and preparation method and application thereof | 河北医科大学 | 2023-08-25 | — | — | CN | claimed |
| CN-116640096-A | 5-fluorouracil-sarcosine eutectic crystal and preparation method and application thereof | 河北医科大学 | 2023-08-25 | — | — | CN | disclosed |
| CN-116640096-A | 5-fluorouracil-sarcosine eutectic crystal and preparation method and application thereof | 河北医科大学 | 2023-08-25 | — | — | CN | disclosed |
| CN-116640096-A | 5-fluorouracil-sarcosine eutectic crystal and preparation method and application thereof | 河北医科大学 | 2023-08-25 | — | — | CN | disclosed |
| CN-113234028-B | 5-fluorouracil and sarcosine cocrystal and preparation method and application thereof | 上海大学 | 2022-08-26 | — | — | CN | disclosed |
| CN-113234028-A | 5-fluorouracil and sarcosine cocrystal and preparation method and application thereof | 上海大学 | 2021-08-10 | — | — | CN | disclosed |