Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 2/20 | 0.36 |
| ▸ | MAOB | P27338 | 2/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | FTO | Q9C0B1 | 2/20 | 0.33 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5501432 | 0.74 | POLB (0.42) | ALDH1A1HPGDCYP3A4MAPTCYP2A6 | |
| SCHEMBL16762286 | 0.74 | MAOA (0.36) | CYP2A6MAOAMAOBNFKB1HTR2A | |
| SCHEMBL16048354 | 0.74 | MAOA (0.36) | MAOAMAOBNFKB1HTR2AHTR2C | |
| SCHEMBL2048407 | 0.74 | ALDH1A1 (0.42) | ALDH1A1HPGDCYP3A4MAPTCYP2A6 | |
| SCHEMBL4429415 | 0.72 | PAX8 (0.48) | ALDH1A1HPGDCYP3A4MAPTCYP2A6 | |
| SCHEMBL4421214 | 0.72 | CYP3A4 (0.68) | ALDH1A1HPGDCYP3A4MAPTCYP2A6 | |
| SCHEMBL2367986 | 0.70 | TDP1 (0.46) | ALDH1A1HPGDCYP3A4MAPTKDM4E | |
| SCHEMBL30382539 | 0.70 | TDP1 (0.46) | ALDH1A1HPGDCYP3A4MAPTKDM4E | |
| SCHEMBL11926014 | 0.69 | ALDH1A1 (0.39) | ALDH1A1HPGDCYP3A4MAPTCYP2A6 | |
| SCHEMBL9079188 | 0.69 | ALDH1A1 (0.42) | ALDH1A1HPGDCYP3A4MAPTCYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4642784-A1 | HETEROCYCLIC AND HETEROARYL COMPOUNDS AS INHIBITORS OF NLRP3 | PTC Therapeutics, Inc. (US) | 2025-11-05 | — | — | EP | disclosed |
| WO-2024145623-A1 | HETEROCYCLIC AND HETEROARYL COMPOUNDS AS INHIBITORS OF NLRP3 | PTC THERAPEUTICS, INC. (US) | 2024-07-04 | — | — | WO | disclosed |
| CN-113087722-B | Tricyclic isoxazole compound and preparation method and application thereof | 中国人民解放军海军军医大学 | 2023-04-28 | — | — | CN | disclosed |
| CN-109438471-B | Tricyclic isoxazole compound and preparation method and application thereof | 中国人民解放军第二军医大学 | 2021-09-17 | — | — | CN | disclosed |
| CN-113087722-A | Tricyclic isoxazole compound and preparation method and application thereof | 中国人民解放军海军军医大学 | 2021-07-09 | — | — | CN | disclosed |