Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 2/20 | 0.36 |
| ▸ | MAOB | P27338 | 2/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 4/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | FTO | Q9C0B1 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28636765 | 0.74 | ALDH1A1 (0.42) | MAOAMAOBNFKB1ALDH1A1CYP3A4 | |
| SCHEMBL5497618 | 0.74 | CYP3A4 (0.39) | MAOAMAOBNFKB1ALDH1A1CYP3A4 | |
| SCHEMBL5986568 | 0.74 | MAOA (0.36) | MAOAMAOBNFKB1HTR2AHTR2C | |
| SCHEMBL2269866 | 0.74 | KDM4E (0.47) | MAOAMAOBNFKB1ALDH1A1CYP3A4 | |
| SCHEMBL17221561 | 0.74 | MAOA (0.36) | MAOAMAOBNFKB1HTR2AHTR2C | |
| SCHEMBL23918657 | 0.74 | ALDH1A1 (0.39) | MAOAMAOBNFKB1ALDH1A1CYP3A4 | |
| SCHEMBL4429415 | 0.72 | PAX8 (0.48) | MAOAMAOBNFKB1ALDH1A1CYP3A4 | |
| SCHEMBL2367630 | 0.70 | POLB (0.56) | POLBALDH1A1KDM4EESR1ESR2 | |
| SCHEMBL30081125 | 0.70 | POLB (0.56) | POLBALDH1A1KDM4EESR1ESR2 | |
| SCHEMBL6194067 | 0.69 | ERN1 (0.47) | MAOAMAOBNFKB1ALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115677616-B | Macrocyclic sulfonamide compound, preparation method and medical application thereof | 中国药科大学 | 2024-10-18 | — | — | CN | disclosed |
| WO-2023078127-A1 | MACROCYCLIC SULFONAMIDE COMPOUND, PREPARATION METHOD THEREFOR, AND MEDICAL USE THEREOF | 中国药科大学 | 2023-05-11 | — | — | WO | disclosed |
| CN-115677616-A | Macrocyclic sulfonamide compound, preparation method and medical application thereof | 中国药科大学 | 2023-02-03 | — | — | CN | disclosed |
| EP-1791807-A1 | THERAPEUTIC DIPHENYL ETHER LIGANDS | Pfizer Products Incorporated (US) | 2007-06-06 | — | — | EP | disclosed |
| WO-2006027684-A1 | THERAPEUTIC DIPHENYL ETHER LIGANDS | PFIZER PRODUCTS INC. (US) | 2006-03-16 | — | — | WO | disclosed |
| US-20060058361-A1 | Therapeutic diphenyl ether ligands | PFIZER INC | 2006-03-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060058361-A1 | Therapeutic diphenyl ether ligands | HTR2B, HTR2C, HTR3B | POLB 2493/4885MAOA 94/4885MAOB 35/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.