Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 18/20 | 0.74 |
| ▸ | MET | P08581 | 8/20 | 0.70 |
| ▸ | MERTK | Q12866 | 5/20 | 0.62 |
| ▸ | AURKA | O14965 | 1/20 | 0.61 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.61 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.61 |
| ▸ | ABL1 | P00519 | 1/20 | 0.61 |
| ▸ | EGFR | P00533 | 1/20 | 0.61 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.61 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.61 |
| ▸ | LCK | P06239 | 1/20 | 0.61 |
| ▸ | PGR | P06401 | 1/20 | 0.61 |
| ▸ | LYN | P07948 | 1/20 | 0.61 |
| ▸ | RET | P07949 | 1/20 | 0.61 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.61 |
| ▸ | HCK | P08631 | 1/20 | 0.61 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.61 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.61 |
| ▸ | KIT | P10721 | 1/20 | 0.61 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29995716 | 0.93 | AXL (0.72) | AXLMETMERTKAURKARIPK2 | |
| SCHEMBL12807168 | 0.92 | MET (0.70) | AXLMETMERTKAURKARIPK2 | |
| SCHEMBL29972991 | 0.92 | MET (0.70) | AXLMETMERTKAURKARIPK2 | |
| SCHEMBL1742894 | 0.92 | MET (0.70) | AXLMETMERTKAURKARIPK2 | |
| Zanzalintinib SCHEMBL29378531 | 0.85 | AXL (1.00) | AXLMETMERTKAURKARIPK2 | |
| Zanzalintinib SCHEMBL21200856 | 0.85 | AXL (1.00) | AXLMETMERTKAURKARIPK2 | |
| Malic Acid SCHEMBL29621016 | 0.84 | MET (0.74) | AXLMETMERTKAURKARIPK2 | |
| SCHEMBL21201281 | 0.83 | AXL (1.00) | AXLMETMERTKAURKARIPK2 | |
| SCHEMBL29995530 | 0.83 | AXL (0.65) | AXLMETMERTKAURKARIPK2 | |
| SCHEMBL30616292 | 0.83 | AXL (0.59) | AXLMETMERTKAURKARIPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118647603-A | Crystalline forms and salt forms of kinase inhibitors | 埃克塞里艾克西斯公司 | 2024-09-13 | — | — | CN | disclosed |
| CN-113939503-B | Crystalline salt forms of kinase inhibitors | 埃克塞里艾克西斯公司 | 2024-05-07 | — | — | CN | disclosed |
| EP-4240333-A1 | PHARMACEUTICAL COMPOSITIONS OF A KINASE INHIBITOR | Exelixis, Inc. (US) | 2023-09-13 | — | — | EP | disclosed |
| CN-116406261-A | Pharmaceutical compositions of kinase inhibitors | 埃克塞里艾克西斯公司 | 2023-07-07 | — | — | CN | disclosed |
| WO-2022098828-A1 | PHARMACEUTICAL COMPOSITIONS OF A KINASE INHIBITOR | EXELIXIS, INC. (US) | 2022-05-12 | — | — | WO | disclosed |
| CN-113939503-A | Crystalline salt forms of a kinase inhibitor | 埃克塞里艾克西斯公司 | 2022-01-14 | — | — | CN | disclosed |
| CN-113329790-A | Crystalline and salt forms of a kinase inhibitor | 埃克塞里艾克西斯公司 | 2021-08-31 | — | — | CN | disclosed |