Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 19/20 | 0.59 |
| ▸ | MERTK | Q12866 | 9/20 | 0.58 |
| ▸ | MET | P08581 | 7/20 | 0.57 |
| ▸ | KDR | P35968 | 3/20 | 0.57 |
| ▸ | RET | P07949 | 2/20 | 0.51 |
| ▸ | KIT | P10721 | 2/20 | 0.51 |
| ▸ | FLT3 | P36888 | 2/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.51 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.51 |
| ▸ | ABL1 | P00519 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.51 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.51 |
| ▸ | LCK | P06239 | 1/20 | 0.51 |
| ▸ | PGR | P06401 | 1/20 | 0.51 |
| ▸ | LYN | P07948 | 1/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.51 |
| ▸ | HCK | P08631 | 1/20 | 0.51 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30616277 | 0.91 | AXL (0.51) | AXLMERTKMETKDRRET | |
| SCHEMBL29995716 | 0.89 | AXL (0.72) | AXLMERTKMETKDRRET | |
| SCHEMBL31570685 | 0.87 | MET (0.67) | AXLMERTKMETKDRRET | |
| SCHEMBL31330325 | 0.85 | AXL (0.61) | AXLMERTKMETKDRRET | |
| SCHEMBL12807168 | 0.83 | MET (0.70) | AXLMERTKMETKDRRET | |
| SCHEMBL1742894 | 0.83 | MET (0.70) | AXLMERTKMETKDRRET | |
| SCHEMBL29972991 | 0.83 | MET (0.70) | AXLMERTKMETKDRRET | |
| SCHEMBL28637610 | 0.83 | AXL (0.74) | AXLMERTKMETKDRRET | |
| SCHEMBL29995530 | 0.81 | AXL (0.65) | AXLMERTKMETKDRRET | |
| SCHEMBL21201052 | 0.81 | AXL (0.86) | AXLMERTKMETKDRRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117402114-A | Compounds for the treatment of kinase dependent disorders | 埃克塞里艾克西斯公司 | 2024-01-16 | — | — | CN | disclosed |
| CN-111757735-B | Compounds for the treatment of kinase dependent disorders | 埃克塞里艾克西斯公司 | 2023-09-22 | — | — | CN | disclosed |