Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 10/20 | 0.70 |
| ▸ | AXL | P30530 | 9/20 | 0.70 |
| ▸ | KDR | P35968 | 4/20 | 0.70 |
| ▸ | MERTK | Q12866 | 3/20 | 0.70 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.70 |
| ▸ | FLT1 | P17948 | 2/20 | 0.70 |
| ▸ | FLT3 | P36888 | 2/20 | 0.70 |
| ▸ | AURKA | O14965 | 1/20 | 0.70 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.70 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.70 |
| ▸ | ABL1 | P00519 | 1/20 | 0.70 |
| ▸ | EGFR | P00533 | 1/20 | 0.70 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.70 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.70 |
| ▸ | LCK | P06239 | 1/20 | 0.70 |
| ▸ | PGR | P06401 | 1/20 | 0.70 |
| ▸ | LYN | P07948 | 1/20 | 0.70 |
| ▸ | RET | P07949 | 1/20 | 0.70 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.70 |
| ▸ | HCK | P08631 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29972991 | 1.00 | MET (0.70) | METAXLKDRMERTKAURKB | |
| SCHEMBL12807168 | 1.00 | MET (0.70) | METAXLKDRMERTKAURKB | |
| SCHEMBL29995716 | 0.94 | AXL (0.72) | METAXLKDRMERTKAURKB | |
| SCHEMBL28637610 | 0.92 | AXL (0.74) | METAXLKDRMERTKAURKB | |
| Malic Acid SCHEMBL29621016 | 0.91 | MET (0.74) | METAXLKDRMERTKAURKB | |
| SCHEMBL31570685 | 0.90 | MET (0.67) | METAXLKDRMERTKAURKB | |
| SCHEMBL16061951 | 0.87 | AXL (0.78) | METAXLKDRMERTKAURKB | |
| SCHEMBL28378727 | 0.87 | PDGFRA (0.57) | METAXLKDRMERTKAURKB | |
| SCHEMBL28710842 | 0.86 | AXL (0.55) | METAXLKDRMERTKAURKB | |
| SCHEMBL30616292 | 0.83 | AXL (0.59) | METAXLKDRMERTKAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4313048-A1 | PROCESS FOR PREPARATION OF CABOZANTINIB | Biocon Limited (IN) | 2024-02-07 | — | — | EP | disclosed |
| CN-110621662-B | Crystalline solid form of salt, preparation process and use method | 埃克塞里艾克西斯公司 | 2023-06-23 | — | — | CN | disclosed |
| CN-110621662-B | Crystalline solid form of salt, preparation process and use method | 埃克塞里艾克西斯公司 | 2023-06-23 | — | — | CN | disclosed |
| WO-2022201079-A1 | PROCESS FOR PREPARATION OF CABOZANTINIB | BIOCON LIMITED (IN) | 2022-09-29 | — | — | WO | disclosed |
| WO-2021209940-A1 | PHARMACEUTICAL COMPOSITION CONTAINING N-(4-(6,7-DIMETHOXYQUINOLIN-4-YLOXY)PHENYL)-N'-(4-FLUOROPHENYL)CYCLOPROPANE-1,1-DICARBOXAMIDE, (2S)-HYDROXYBUTANEDIOATE | MSN LABORATORIES PRIVATE LIMITED, R&D CENTER (IN) | 2021-10-21 | — | — | WO | disclosed |
| EP-2387563-A1 | Malate salt of n- (4- { [ 6, 7-bis (methyloxy) quin0lin-4-yl]oxy}phenyl-n' - (4 -fluorophenyl) cyclopropane-1-dicarboxamide, and crystalline forms therof for the treatment of cancer | Exelixis, Inc. (US) | 2011-11-23 | — | — | EP | disclosed |
| US-20110252754-A1 | HORSEBACK RIDING SPUR MECHANISM | COOK KARL | 2011-10-20 | — | — | US | disclosed |
| WO-2010083414-A1 | MALATE SALT OF N- (4- { [ 6, 7-BIS (METHYLOXY) QUIN0LIN-4-YL] OXY}PHENYL-N' - (4 -FLUOROPHENYL) CYCLOPROPANE-1-DICARBOXAMIDE, AND CRYSTALLINE FORMS THEROF FOR THE TREATMENT OF CANCER | EXELIXIS, INC. (US) | 2010-07-22 | — | — | WO | disclosed |