Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 10/20 | 0.70 |
| ▸ | AXL | P30530 | 9/20 | 0.70 |
| ▸ | KDR | P35968 | 4/20 | 0.70 |
| ▸ | MERTK | Q12866 | 3/20 | 0.70 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.70 |
| ▸ | FLT1 | P17948 | 2/20 | 0.70 |
| ▸ | FLT3 | P36888 | 2/20 | 0.70 |
| ▸ | AURKA | O14965 | 1/20 | 0.70 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.70 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.70 |
| ▸ | ABL1 | P00519 | 1/20 | 0.70 |
| ▸ | EGFR | P00533 | 1/20 | 0.70 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.70 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.70 |
| ▸ | LCK | P06239 | 1/20 | 0.70 |
| ▸ | PGR | P06401 | 1/20 | 0.70 |
| ▸ | LYN | P07948 | 1/20 | 0.70 |
| ▸ | RET | P07949 | 1/20 | 0.70 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.70 |
| ▸ | HCK | P08631 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29972991 | 1.00 | MET (0.70) | METAXLKDRMERTKAURKB | |
| SCHEMBL1742894 | 1.00 | MET (0.70) | METAXLKDRMERTKAURKB | |
| SCHEMBL29995716 | 0.94 | AXL (0.72) | METAXLKDRMERTKAURKB | |
| SCHEMBL28637610 | 0.92 | AXL (0.74) | METAXLKDRMERTKAURKB | |
| Malic Acid SCHEMBL29621016 | 0.91 | MET (0.74) | METAXLKDRMERTKAURKB | |
| SCHEMBL31570685 | 0.90 | MET (0.67) | METAXLKDRMERTKAURKB | |
| SCHEMBL16061951 | 0.87 | AXL (0.78) | METAXLKDRMERTKAURKB | |
| SCHEMBL28378727 | 0.87 | PDGFRA (0.57) | METAXLKDRMERTKAURKB | |
| SCHEMBL28710842 | 0.86 | AXL (0.55) | METAXLKDRMERTKAURKB | |
| SCHEMBL30616292 | 0.83 | AXL (0.59) | METAXLKDRMERTKAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10736886-B2 | Methods of using c-Met modulators | EXELIXIS, INC. (US) | 2020-08-11 | — | — | US | claimed |
| US-20220175757-A1 | Processes for Preparing Quinoline Compounds and Pharmaceutical Compositions Containing Such Compounds | EXELIXIS, INC. | 2022-06-09 | — | — | US | disclosed |
| US-11298349-B2 | Processes for preparing quinoline compounds and pharmaceutical compositions containing such compounds | EXELIXIS, INC. (US) | 2022-04-12 | — | — | US | disclosed |
| US-20210161885-A1 | Processes for Preparing Quinoline Compounds and Pharmaceutical Compositions Containing Such Compounds | EXELIXIS, INC. | 2021-06-03 | — | — | US | disclosed |
| US-20200255382-A1 | Method of Treating Cancer and Bone Cancer Pain | EXELIXIS, INC. | 2020-08-13 | — | — | US | disclosed |
| US-20150202196-A1 | Methods of Using C-Met Modulators | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2015-07-23 | — | — | US | disclosed |
| US-20120252840-A1 | Method of Treating Cancer | EXELIXIS, INC. (US) | 2012-10-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200255382-A1 | Method of Treating Cancer and Bone Cancer Pain | TPO, OGFR, CALCR | MET 78/4885AXL 3057/4885KDR 2332/4885 |
| US-20120252840-A1 | Method of Treating Cancer | MET, FLT1, TIE1 | MET 1/4885AXL 1156/4885KDR 4/4885 |
| US-11298349-B2 | Processes for preparing quinoline compounds and pharmaceutical compositions containing such compounds | HAX1, HRH1, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | MET 4434/4885AXL 4403/4885KDR 4574/4885 |
| US-20150202196-A1 | Methods of Using C-Met Modulators | MET, KRAS, HGF | MET 1/4885AXL 2418/4885KDR 603/4885 |
| US-20220175757-A1 | Processes for Preparing Quinoline Compounds and Pharmaceutical Compositions Containing Such Compounds | HAX1, HRH1, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | MET 4434/4885AXL 4403/4885KDR 4574/4885 |
| US-20210161885-A1 | Processes for Preparing Quinoline Compounds and Pharmaceutical Compositions Containing Such Compounds | HAX1, HRH1, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | MET 4434/4885AXL 4403/4885KDR 4574/4885 |
| US-10736886-B2 | Methods of using c-Met modulators | MET, KRAS, HGF | MET 1/4885AXL 2270/4885KDR 157/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.