Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Triclofos. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR3 | Q9UBY5 | 7/20 | 0.44 |
| ▸ | LPAR1 | Q92633 | 5/20 | 0.44 |
| ▸ | LPAR2 | Q9HBW0 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 8/20 | 0.37 |
| ▸ | S1PR3 | Q99500 | 6/20 | 0.37 |
| ▸ | S1PR4 | O95977 | 4/20 | 0.37 |
| ▸ | S1PR5 | Q9H228 | 4/20 | 0.37 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.36 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL37203 | 0.92 | LPAR3 (0.52) | LPAR3LPAR1LPAR2CYP3A4S1PR1 | |
| SCHEMBL2864012 | 0.88 | CYP3A4 (0.37) | LPAR3LPAR1LPAR2CYP3A4S1PR1 | |
| Triclofos SCHEMBL2864015 | 0.86 | LPAR3 (0.38) | LPAR3LPAR1LPAR2CYP3A4S1PR1 | |
| SCHEMBL9633561 | 0.84 | LPAR3 (0.68) | LPAR3LPAR1LPAR2CYP3A4S1PR1 | |
| SCHEMBL14841933 | 0.81 | LPAR3 (0.42) | LPAR3LPAR1LPAR2CYP3A4S1PR1 | |
| SCHEMBL27986969 | 0.79 | LPAR3 (0.42) | LPAR3LPAR1LPAR2CYP3A4 | |
| SCHEMBL31606640 | 0.77 | CYP3A4 (0.58) | LPAR3LPAR1LPAR2CYP3A4 | |
| Triclofos SCHEMBL125854 | 0.76 | FBP1 (0.38) | LPAR3LPAR1LPAR2S1PR1S1PR3 | |
| SCHEMBL27933587 | 0.76 | LPAR3 (0.41) | LPAR3LPAR1LPAR2S1PR1S1PR3 | |
| Triphenyl Phosphate SCHEMBL28210904 | 0.75 | SRC (0.41) | S1PR1S1PR3S1PR4S1PR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767380-B2 | Photopolymerization type photosensitive lithographic printing plate precursor | FUJIFILM CORPORATION (JP) | 2010-08-03 | — | — | US | disclosed |
| US-20080076066-A1 | PHOTOPOLYMERIZATION TYPE PHOTOSENSITIVE LITHOGRAPHIC PRINTING PLATE PRECURSOR | FUJIFILM CORPORATION (JP) | 2008-03-27 | — | — | US | disclosed |