Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 3/20 | 0.51 |
| ▸ | BRD4 | O60885 | 1/20 | 0.48 |
| ▸ | BRAF | P15056 | 4/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.46 |
| ▸ | CDK2 | P24941 | 2/20 | 0.46 |
| ▸ | TTK | P33981 | 2/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.41 |
| ▸ | RAF1 | P04049 | 3/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | AXL | P30530 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3435046 | 0.86 | BRD4 (0.56) | METAP2BRD4BRAFCCNA2CDK2 | |
| SCHEMBL2880810 | 0.83 | METAP2 (0.47) | METAP2BRD4BRAFCCNA2CDK2 | |
| SCHEMBL28640314 | 0.81 | PIK3CA (0.52) | METAP2BRD4BRAFTTKPIK3CA | |
| SCHEMBL3435032 | 0.80 | PIK3CA (0.42) | METAP2BRD4BRAFPIM1CCNA2 | |
| SCHEMBL3435505 | 0.80 | METAP2 (0.48) | METAP2BRD4BRAFCCNA2CDK2 | |
| SCHEMBL2879628 | 0.75 | BRD4 (0.50) | METAP2BRD4BRAFPIK3CAMEN1 | |
| SCHEMBL28961950 | 0.74 | BRAF (0.61) | METAP2BRD4BRAFPIK3CAMEN1 | |
| SCHEMBL28635804 | 0.70 | BRAF (0.51) | METAP2BRD4BRAFPIK3CAMEN1 | |
| SCHEMBL3435497 | 0.70 | METAP2 (0.46) | METAP2BRD4BRAFPIK3CAPIK3CD | |
| SCHEMBL15876525 | 0.70 | METAP2 (0.44) | METAP2BRD4BRAFPIK3CALRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2252616-A1 | PYRAZOLOPYRIMIDINE PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | Genentech, Inc. (US) | 2010-11-24 | — | — | EP | claimed |
| WO-2009097446-A1 | PYRAZOLOPYRIMIDINE PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2009-08-06 | — | — | WO | claimed |
| CN-106659765-B | Use of dianhydrogalactitol and analogs or derivatives thereof for treating non-small cell lung cancer and ovarian cancer | 德玛医药 | 2021-08-13 | — | — | CN | disclosed |