SCHEMBL28640757

SCHEMBL28640757

FC(=Cc1ccc2ccccc2c1)c1ccccc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RELA Q04206 1/20 0.50
KDM4E B2RXH2 1/20 0.47
ALDH1A1 P00352 1/20 0.47
L3MBTL1 Q9Y468 1/20 0.47
PLAU P00749 1/20 0.45
PTGS1 P23219 1/20 0.44
AKR1C3 P42330 1/20 0.43
LMNA P02545 1/20 0.41
HTT P42858 1/20 0.41
GRIN2D O15399 2/20 0.41
GRIN3B O60391 2/20 0.41
GRIN1 Q05586 2/20 0.41
GRIN2A Q12879 2/20 0.41
GRIN2B Q13224 2/20 0.41
GRIN2C Q14957 2/20 0.41
GRIN3A Q8TCU5 2/20 0.41
CYP1A1 P04798 1/20 0.40
CYP1A2 P05177 1/20 0.40
CYP3A4 P08684 1/20 0.40
CYP2D6 P10635 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28640754 1.00 RELA (0.50) RELAKDM4EALDH1A1L3MBTL1PLAU
SCHEMBL28644641 0.86 PTPN1 (0.56) RELAKDM4EALDH1A1L3MBTL1PLAU
SCHEMBL28634301 0.86 PTPN1 (0.56) RELAKDM4EALDH1A1L3MBTL1PLAU
SCHEMBL28641298 0.86 CYP2A6 (0.46) RELAKDM4EALDH1A1L3MBTL1PTGS1
SCHEMBL28634303 0.86 PTPN1 (0.56) RELAKDM4EALDH1A1L3MBTL1PLAU
SCHEMBL28633606 0.86 CYP2A6 (0.46) RELAKDM4EALDH1A1L3MBTL1PTGS1
SCHEMBL28633610 0.86 CYP2A6 (0.46) RELAKDM4EALDH1A1L3MBTL1PTGS1
Benzene SCHEMBL29278546 0.82 RELA (0.55) RELAKDM4EALDH1A1L3MBTL1PLAU
SCHEMBL10646653 0.81 RELA (0.53) RELAKDM4EALDH1A1L3MBTL1PLAU
SCHEMBL29639038 0.80 ALDH1A1 (0.53) RELAKDM4EALDH1A1L3MBTL1PTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104447521-B Reagent for preparing high-selectivity monofluoroolefin 中国科学院上海有机化学研究所 2021-09-03 CN disclosed