Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 3/20 | 0.40 |
| ▸ | LOXL3 | P58215 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 2/20 | 0.35 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.35 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.35 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.35 |
| ▸ | CCND1 | P24385 | 1/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.35 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.35 |
| ▸ | ITK | Q08881 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.34 |
| ▸ | SELE | P16581 | 2/20 | 0.34 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28643913 | 0.89 | LOXL2 (0.38) | LOXL2LOXL3NTRK1CDK2CCNB2 | |
| SCHEMBL28644238 | 0.83 | LOXL2 (0.41) | LOXL2LOXL3NTRK1CDK2CCNB2 | |
| SCHEMBL28663602 | 0.81 | SIRT2 (0.44) | LOXL2LOXL3NTRK1SMN1; SMN2MAPK1 | |
| SCHEMBL28643912 | 0.81 | LOXL2 (0.41) | LOXL2LOXL3CDK2CCNE2CCNE1 | |
| SCHEMBL28641774 | 0.81 | LOXL2 (0.48) | LOXL2LOXL3 | |
| SCHEMBL28643885 | 0.80 | LOXL3 (0.36) | LOXL2LOXL3NTRK1CDK2CCNB2 | |
| SCHEMBL28657391 | 0.79 | LOXL2 (0.43) | LOXL2LOXL3NTRK1TSHR | |
| SCHEMBL19259774 | 0.79 | LOXL2 (0.38) | LOXL2LOXL3NTRK1CDK2CCNE2 | |
| SCHEMBL28638875 | 0.79 | LOXL2 (0.46) | LOXL2LOXL3 | |
| SCHEMBL19259767 | 0.77 | LOXL2 (0.48) | LOXL2LOXL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109311839-B | Methylamine derivatives as lysyl oxidase inhibitors for the treatment of cancer | 癌症研究协会皇家癌症医院 | 2021-11-02 | — | — | CN | disclosed |