Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.44 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.44 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.44 |
| ▸ | LOXL2 | Q9Y4K0 | 3/20 | 0.39 |
| ▸ | LOX | P28300 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.39 |
| ▸ | LOXL3 | P58215 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.37 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28657391 | 0.88 | LOXL2 (0.43) | SIRT2SIRT1SIRT3LOXL2LOXL3 | |
| SCHEMBL28644238 | 0.87 | LOXL2 (0.41) | SIRT1LOXL2LOXL3NTRK1LMNA | |
| SCHEMBL28644286 | 0.82 | LOXL2 (0.41) | SIRT2SIRT1SIRT3LOXL2LOX | |
| SCHEMBL28645865 | 0.81 | LOXL2 (0.40) | LOXL2LOXL3NTRK1LMNASMN1; SMN2 | |
| SCHEMBL28643885 | 0.81 | LOXL3 (0.36) | LOXL2LOXL3NTRK1NPC1LMNA | |
| SCHEMBL28644194 | 0.81 | LOXL2 (0.42) | LOXL2LOXLOXL3NTRK1HTT | |
| SCHEMBL28651627 | 0.81 | SIRT2 (0.43) | SIRT2SIRT1SIRT3LOXL2HTT | |
| SCHEMBL28657397 | 0.80 | LOXL2 (0.41) | LOXL2LOXL3NTRK1HTTNPC1 | |
| SCHEMBL28651596 | 0.78 | ALDH1A1 (0.42) | LOXL2LOXL3LMNARAB9AKMT2A | |
| SCHEMBL19259976 | 0.78 | ABL1 (0.40) | SIRT2SIRT1SIRT3LOXL2LOX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109311839-B | Methylamine derivatives as lysyl oxidase inhibitors for the treatment of cancer | 癌症研究协会皇家癌症医院 | 2021-11-02 | — | — | CN | disclosed |