Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 2/20 | 0.49 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.48 |
| ▸ | MEN1 | O00255 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | ACLY | P53396 | 3/20 | 0.47 |
| ▸ | WDR5 | P61964 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28657757 | 0.91 | METAP2 (0.52) | METAP2PFKFB3KMT2AMEN1KDM4E | |
| SCHEMBL28637411 | 0.88 | ACLY (0.55) | METAP2PFKFB3KMT2AMEN1KDM4E | |
| SCHEMBL28926556 | 0.85 | WDR5 (0.57) | PFKFB3KMT2AMEN1KDM4EPOLB | |
| SCHEMBL28925275 | 0.85 | ACLY (0.49) | PFKFB3KMT2AMEN1KDM4EPOLB | |
| SCHEMBL28925257 | 0.84 | MEN1 (0.52) | PFKFB3KMT2AMEN1KDM4EPOLB | |
| SCHEMBL28657550 | 0.84 | MEN1 (0.50) | PFKFB3KMT2AMEN1KDM4EPOLB | |
| SCHEMBL28637197 | 0.84 | MEN1 (0.50) | PFKFB3KMT2AMEN1KDM4EPOLB | |
| SCHEMBL28652663 | 0.84 | PFKFB3 (0.55) | PFKFB3KMT2AMEN1KDM4EPOLB | |
| SCHEMBL28653065 | 0.82 | PFKFB3 (0.48) | PFKFB3KMT2AMEN1KDM4EPOLB | |
| SCHEMBL2747563 | 0.80 | ACLY (0.52) | METAP2PFKFB3MCL1ACLYLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113396145-A | PFKFB3 inhibitors and uses thereof | 盖罗发现有限责任公司 | 2021-09-14 | — | — | CN | disclosed |