Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Rebamipide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UBASH3B | Q8TF42 | 1/20 | 0.94 |
| ▸ | PPARG | P37231 | 1/20 | 0.53 |
| ▸ | ITGB2 | P05107 | 6/20 | 0.52 |
| ▸ | ICAM1 | P05362 | 6/20 | 0.52 |
| ▸ | ITGAL | P20701 | 6/20 | 0.52 |
| ▸ | F11 | P03951 | 2/20 | 0.52 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.52 |
| ▸ | TACR1 | P25103 | 2/20 | 0.50 |
| ▸ | CCKBR | P32239 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Rebamipide SCHEMBL23346201 | 0.97 | UBASH3B (1.00) | UBASH3BPPARGITGB2ICAM1ITGAL | |
| Rebamipide SCHEMBL29560992 | 0.97 | UBASH3B (1.00) | UBASH3BPPARGITGB2ICAM1ITGAL | |
| Rebamipide SCHEMBL221527 | 0.97 | UBASH3B (1.00) | UBASH3BPPARGITGB2ICAM1ITGAL | |
| Rebamipide SCHEMBL5794018 | 0.97 | UBASH3B (1.00) | UBASH3BPPARGITGB2ICAM1ITGAL | |
| Rebamipide SCHEMBL21623658 | 0.97 | UBASH3B (1.00) | UBASH3BPPARGITGB2ICAM1ITGAL | |
| Rebamipide SCHEMBL9114879 | 0.96 | UBASH3B (0.98) | UBASH3BPPARGITGB2ICAM1ITGAL | |
| Rebamipide SCHEMBL28798513 | 0.96 | UBASH3B (0.98) | UBASH3BPPARGITGB2ICAM1ITGAL | |
| Rebamipide SCHEMBL2292009 | 0.96 | UBASH3B (0.98) | UBASH3BPPARGITGB2ICAM1ITGAL | |
| Rebamipide SCHEMBL27858766 | 0.96 | UBASH3B (0.98) | UBASH3BPPARGITGB2ICAM1ITGAL | |
| Rebamipide SCHEMBL27819911 | 0.96 | UBASH3B (0.98) | UBASH3BPPARGITGB2ICAM1ITGAL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108853030-B | Medicinal preparation for treating malignant tumor and preparation method thereof | 上海朝晖药业有限公司 | 2021-10-01 | — | — | CN | claimed |
| CN-108853030-B | Medicinal preparation for treating malignant tumor and preparation method thereof | 上海朝晖药业有限公司 | 2021-10-01 | — | — | CN | disclosed |