SCHEMBL28648372

SCHEMBL28648372

COCc1cc[c]c(OC(F)(F)F)c1

nearest known ligand 0.35

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
PDK2 Q15119 1/20 0.35
MRGPRX4 Q96LA9 1/20 0.33
DYRK1A Q13627 1/20 0.33
PTPN1 P18031 1/20 0.32
BACE1 P56817 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28009292 0.77 LTA4H (0.44)
SCHEMBL1066850 0.74 NPC1 (0.35) PDK2
SCHEMBL28008873 0.73 PTPN5 (0.35)
SCHEMBL28009285 0.73 CYP17A1 (0.33)
SCHEMBL21268345 0.73 CBFB (0.39) DYRK1A
SCHEMBL1067464 0.73 GPR3 (0.38)
SCHEMBL16741078 0.73 PDK2 (0.33) PDK2PTPN1
SCHEMBL22683446 0.73 AURKA (0.32)
SCHEMBL1510448 0.72 FFAR1 (0.45)
SCHEMBL28009293 0.72 IDO1 (0.39)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113573713-A Ion channel modulators 普拉克西斯精密药物股份有限公司 2021-10-29 CN disclosed