Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TERT | O14746 | 10/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.33 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 2/20 | 0.32 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2882063 | 0.78 | TERT (0.36) | TERTJAK2MCHR1CCNT1CDK9 | |
| SCHEMBL3500170 | 0.76 | JAK2 (0.61) | JAK2ITGB3ITGA2BEGFR | |
| SCHEMBL2867290 | 0.64 | JAK2 (0.50) | TERTJAK2CCNT1CDK9 | |
| SCHEMBL14816847 | 0.59 | HDAC3 (0.64) | HDAC3HDAC1HDAC6 | |
| SCHEMBL10612618 | 0.55 | MAPT (0.62) | HDAC3HDAC1HDAC6 | |
| SCHEMBL3238446 | 0.54 | GNG2 (0.71) | — | |
| SCHEMBL1520594 | 0.53 | CYP3A4 (0.67) | — | |
| SCHEMBL7093999 | 0.53 | ALDH1A1 (0.58) | — | |
| SCHEMBL2470801 | 0.53 | L3MBTL1 (0.66) | EGFRHDAC3HDAC1HDAC6 | |
| SCHEMBL15480436 | 0.52 | HDAC3 (0.49) | HDAC3HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2200612-A1 | INHIBITORS OF JANUS KINASES | Merck Sharp & Dohme Corp. (US) | 2010-06-30 | — | — | EP | disclosed |
| WO-2009035575-A1 | INHIBITORS OF JANUS KINASES | MERCK & CO., INC. (US) | 2009-03-19 | — | — | WO | disclosed |