SCHEMBL28652018

SCHEMBL28652018

Nc1c(Br)cc(Br)cc1C(Br)Br

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 1/20 0.40
MAPT P10636 1/20 0.40
GSK3B P49841 1/20 0.38
CYP3A4 P08684 3/20 0.35
TSHR P16473 2/20 0.35
TDP1 Q9NUW8 2/20 0.35
GABRA1 P14867 2/20 0.33
GABRB1 P18505 2/20 0.33
HTT P42858 2/20 0.33
KMT2A Q03164 1/20 0.33
CA1 P00915 1/20 0.33
CA2 P00918 1/20 0.33
CA3 P07451 1/20 0.33
CA9 Q16790 1/20 0.33
CYP2D6 P10635 2/20 0.31
SLC6A4 P31645 2/20 0.31
KCNH2 Q12809 2/20 0.31
LMNA P02545 2/20 0.31
GABRA2 P47869 1/20 0.31
GABRB2 P47870 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17262069 0.79 GABRA1 (0.52) GAAMAPTGSK3BCYP3A4TSHR
SCHEMBL29210 0.76 GAA (0.65) GAAMAPTGSK3BCYP3A4TSHR
SCHEMBL253259 0.73 GABRA1 (0.36) GAAMAPTCYP3A4TSHRGABRA1
SCHEMBL28651893 0.71 MAPT (0.43) GAAMAPTGSK3BTDP1
SCHEMBL10779859 0.71 TDP1 (0.35) CYP3A4TSHRTDP1GABRA1GABRB1
SCHEMBL28530991 0.71 IDO1 (0.40) GAAMAPTKMT2ASLC6A4SLC6A2
SCHEMBL9388166 0.69 GAA (0.48) GAAMAPTGSK3BCYP3A4TSHR
SCHEMBL1612647 0.69 GAA (0.48) GAAMAPTGSK3BCYP3A4TSHR
SCHEMBL29674869 0.69 GAA (0.48) GAAMAPTGSK3BCYP3A4TSHR
SCHEMBL20621462 0.68 ADRB2 (0.33) CYP3A4GABRA1GABRB1HTTCYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113444004-A Production process of 3, 5-dibromo anthranilic aldehyde 江西荣兴药业有限公司 2021-09-28 CN claimed
CN-113444004-A Production process of 3, 5-dibromo anthranilic aldehyde 江西荣兴药业有限公司 2021-09-28 CN disclosed