Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | AR | P10275 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20180215 | 0.85 | GABRA1 (0.45) | GABRA1GABRB1TSHRGAAAR | |
| SCHEMBL20621462 | 0.82 | ADRB2 (0.33) | GABRA1GABRB1CYP2D6SLC6A4KCNH2 | |
| SCHEMBL24227156 | 0.81 | OPRM1 (0.34) | GABRA1GABRB1CYP2D6SLC6A4KCNH2 | |
| SCHEMBL17262069 | 0.79 | GABRA1 (0.52) | GABRA1GABRB1TSHRGAACYP2D6 | |
| SCHEMBL7068142 | 0.77 | GABRA1 (0.50) | GABRA1GABRB1TSHRGAAUSP2 | |
| SCHEMBL7156139 | 0.77 | GABRA1 (0.36) | GABRA1GABRB1TSHRRORC | |
| SCHEMBL342170 | 0.74 | TSHR (0.38) | TSHRGAAARUSP2ALDH1A1 | |
| SCHEMBL250536 | 0.73 | TSHR (0.47) | GABRA1GABRB1TSHRGAAUSP2 | |
| SCHEMBL249883 | 0.73 | HPGD (0.41) | GABRA1GABRB1TSHRGAAAR | |
| SCHEMBL28652018 | 0.73 | GAA (0.40) | GABRA1GABRB1TSHRGAACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130217783-A1 | Therapeutic Compounds | SIGNATURE THERAPEUTICS, INC. (US) | 2013-08-22 | — | — | US | disclosed |
| US-8350097-B2 | Therapeutic compounds | SIGNATURE THERAPEUTICS, INC. (US) | 2013-01-08 | — | — | US | disclosed |
| US-20120196939-A1 | Therapeutic Compounds | SOWOOD HEALTHCARE LLC | 2012-08-02 | — | — | US | disclosed |
| US-8173849-B2 | Therapeutic compounds | SIGNATURE THERAPEUTICS, INC. (US) | 2012-05-08 | — | — | US | disclosed |
| EP-2152651-B1 | THERAPEUTIC COMPOUNDS | PHARMACOFORE INC (US) | 2012-01-04 | — | — | EP | disclosed |
| EP-2392559-A1 | Therapeutic compounds | Pharmacofore, Inc. (US) | 2011-12-07 | — | — | EP | disclosed |
| US-20100249246-A1 | Therapeutic Compounds | PHARMACOFORE, INC. (US) | 2010-09-30 | — | — | US | disclosed |
| EP-2152651-A1 | THERAPEUTIC COMPOUNDS | Pharmacofore, Inc. (US) | 2010-02-17 | — | — | EP | disclosed |
| WO-2008141099-A1 | THERAPEUTIC COMPOUNDS | PHARMACOFORE, INC. (US) | 2008-11-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130217783-A1 | Therapeutic Compounds | OPRM1, OGFR, UGT1A1 | GABRA1 202/4885GABRB1 189/4885TSHR 1530/4885 |
| US-20100249246-A1 | Therapeutic Compounds | OPRM1, OGFR, UGT1A1 | GABRA1 202/4885GABRB1 189/4885TSHR 1530/4885 |
| US-20120196939-A1 | Therapeutic Compounds | OPRM1, OPRD1, SCN1B | GABRA1 84/4885GABRB1 82/4885TSHR 1877/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.