Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.35 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.35 |
| ▸ | PLOD1 | Q02809 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.30 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30606641 | 0.82 | ELANE (0.43) | HSP90AA1P2RX7 | |
| SCHEMBL3657194 | 0.77 | HSP90AA1 (0.41) | KDRBRAFMAPK14TNNI3KHSP90AA1 | |
| SCHEMBL3170356 | 0.76 | KDM4E (0.40) | — | |
| Trifluoroacetic Acid SCHEMBL30271810 | 0.76 | SLC22A12 (0.42) | KDRBRAFMAPK14TNNI3KP2RX7 | |
| SCHEMBL8390998 | 0.76 | HSP90AA1 (0.45) | KDRBRAFMAPK14TNNI3KHSP90AA1 | |
| SCHEMBL12470613 | 0.76 | HSP90AA1 (0.40) | KDRBRAFMAPK14TNNI3KHSP90AA1 | |
| SCHEMBL2788170 | 0.76 | P2RX7 (0.43) | KDRBRAFMAPK14TNNI3KHSP90AA1 | |
| SCHEMBL29080505 | 0.74 | HSP90AA1 (0.39) | KDRBRAFMAPK14TNNI3KHSP90AA1 | |
| SCHEMBL30575119 | 0.74 | HSP90AA1 (0.39) | KDRBRAFMAPK14TNNI3KHSP90AA1 | |
| SCHEMBL30664890 | 0.73 | HSD17B10 (0.48) | KDRBRAFMAPK14TNNI3KPLOD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112996794-A | Fused heterocyclic compounds as RET kinase inhibitors | 阿雷生物药品公司 | 2021-06-18 | — | — | CN | disclosed |