Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 2/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CCR1 | P32246 | 1/20 | 0.37 |
| ▸ | CCR5 | P51681 | 1/20 | 0.37 |
| ▸ | CCR8 | P51685 | 1/20 | 0.37 |
| ▸ | METAP1 | P53582 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methylamine SCHEMBL20479964 | 0.95 | TSHR (0.40) | KDM4ETSHRCES1CES2LMNA | |
| SCHEMBL9685375 | 0.92 | KDM4E (0.41) | KDM4ETSHRCES1CES2LMNA | |
| SCHEMBL11717509 | 0.81 | ELANE (0.47) | TSHRCES1CES2LMNAP4HTM | |
| Trifluoroacetic Acid SCHEMBL29220444 | 0.80 | CHIT1 (0.40) | KDM4ETSHRCES1CES2LMNA | |
| SCHEMBL11865903 | 0.78 | CES2 (0.46) | KDM4ETSHRCES1CES2LMNA | |
| SCHEMBL450118 | 0.78 | CES2 (0.46) | KDM4ETSHRCES1CES2LMNA | |
| SCHEMBL28655835 | 0.76 | KDR (0.40) | — | |
| SCHEMBL3676096 | 0.76 | CES2 (0.45) | KDM4ETSHRCES1CES2LMNA | |
| SCHEMBL101751 | 0.76 | LMNA (0.48) | KDM4ETSHRCES1CES2LMNA | |
| SCHEMBL28960343 | 0.76 | CES2 (0.45) | KDM4ETSHRCES1CES2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 72 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2985286-B1 | MIDBODY OF TICAGRELOR AND PREPARATION METHOD THEREFOR, AND PREPARATION METHOD FOR TICAGRELOR | JIANGSU HENGRUI MEDICINE CO (CN) | 2017-10-11 | — | — | EP | claimed |
| US-9359366-B2 | Intermediate of Ticagrelor and preparation method therefor, and preparation method for Ticagrelor | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2016-06-07 | — | — | US | claimed |
| US-20160052928-A1 | INTERMEDIATE OF TICAGRELOR AND PREPARATION METHOD THEREFOR, AND PREPARATION METHOD FOR TICAGRELOR | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2016-02-25 | — | — | US | claimed |
| EP-2985286-A1 | MIDBODY OF TICAGRELOR AND PREPARATION METHOD THEREFOR, AND PREPARATION METHOD FOR TICAGRELOR | Jiangsu Hengrui Medicine Co. Ltd. (CN) | 2016-02-17 | — | — | EP | claimed |
| US-7420063-B2 | Process for preparing a dipeptidyl peptidase IV inhibitor and intermediates employed therein | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-09-02 | — | — | US | claimed |
| WO-2005073185-A1 | NOVEL ALKYL- AND ARYL-THIOTRIFLUOROACETATES AND PROCESS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-08-11 | — | — | WO | claimed |
| US-20050159612-A1 | Novel alkyl- and aryl-thiotrifluoroacetates and process | BRISTOL-MYERS SQUIBB COMPANY | 2005-07-21 | — | — | US | claimed |
| EP-0204535-B1 | N-FLUOROPYRIDINIUM SALT AND PROCESS FOR PREPARING SAME | SAGAMI CHEMICAL RESEARCH CENTER (JP) | 1992-08-19 | — | — | EP | claimed |
| CN-108368107-A | FUSED HETEROCYCLIC COMPOUNDS AS S1P MODULATORS | 艾伯维公司 | 2018-08-03 | — | — | CN | disclosed |
| EP-2985286-B1 | MIDBODY OF TICAGRELOR AND PREPARATION METHOD THEREFOR, AND PREPARATION METHOD FOR TICAGRELOR | JIANGSU HENGRUI MEDICINE CO (CN) | 2017-10-11 | — | — | EP | disclosed |
| US-9676777-B2 | Compounds useful for producing an optically active diazabicyclooctane compound | MEIJI SEIKA PHARMA CO., LTD. (JP) | 2017-06-13 | — | — | US | disclosed |
| EP-2657234-B1 | OPTICALLY-ACTIVE DIAZABICYCLOOCTANE DERIVATIVE AND METHOD FOR MANUFACTURING SAME | MEIJI SEIKA PHARMA CO LTD (JP) | 2017-01-11 | — | — | EP | disclosed |
| US-9359366-B2 | Intermediate of Ticagrelor and preparation method therefor, and preparation method for Ticagrelor | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2016-06-07 | — | — | US | disclosed |
| US-20160137645-A1 | COMPOUNDS USEFUL FOR PRODUCING AN OPTICALLY ACTIVE DIAZABICYCLOOCTANE COMPOUND | MEIJI SEIKA PHARMA CO., LTD. (JP) | 2016-05-19 | — | — | US | disclosed |
| WO-1995025110-A1 | HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1995-09-21 | — | — | WO | disclosed |
| EP-0671401-A1 | Beta lactames | F. HOFFMANN-LA ROCHE AG (CH) | 1995-09-13 | — | — | EP | disclosed |
| EP-0494770-B1 | Method for preparing N-fluoropyridinium salts | ONODA CEMENT CO LTD (JP) | 1995-05-10 | — | — | EP | disclosed |
| US-5336772-A | Reacting pyridine compound, fluorine and Bronsted acid in specified ratios | ONODA CEMENT CO., LTD. (JP) | 1994-08-09 | — | — | US | disclosed |
| EP-0494770-A1 | Method for preparing N-fluoropyridinium salts | ONODA CEMENT COMPANY, LTD. (JP) | 1992-07-15 | — | — | EP | disclosed |
| US-4996320-A | Thyroid inhibitors | SAGAMI CHEMICAL RESEARCH CENTER (JP) | 1991-02-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160052928-A1 | INTERMEDIATE OF TICAGRELOR AND PREPARATION METHOD THEREFOR, AND PREPARATION METHOD FOR TICAGRELOR | POR, CYP2C19, TKFC | KDM4E 3537/4885TSHR 2007/4885CES1 966/4885 |
| US-20160137645-A1 | COMPOUNDS USEFUL FOR PRODUCING AN OPTICALLY ACTIVE DIAZABICYCLOOCTANE COMPOUND | CBR1, CBR3, DOHH | KDM4E 4206/4885TSHR 1104/4885CES1 1297/4885 |
| US-20050159612-A1 | Novel alkyl- and aryl-thiotrifluoroacetates and process | TAF9, TAF1, TAF1L | KDM4E 1738/4885TSHR 126/4885CES1 1414/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.