SCHEMBL28656106

SCHEMBL28656106

C1=CC(c2ccccc2)N(Cc2ccccc2)C=C1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 2/20 0.36
SIGMAR1 Q99720 1/20 0.35
MEN1 O00255 2/20 0.35
KMT2A Q03164 2/20 0.35
ALDH1A1 P00352 2/20 0.35
KDM4E B2RXH2 1/20 0.35
LMNA P02545 1/20 0.35
MAPT P10636 1/20 0.35
TSHR P16473 2/20 0.35
HPGD P15428 1/20 0.35
ELANE P08246 2/20 0.34
F2 P00734 1/20 0.34
PLG P00747 1/20 0.34
CTSG P08311 1/20 0.34
CMA1 P23946 1/20 0.34
CTRC Q99895 1/20 0.34
ABCB1 P08183 1/20 0.34
CALM1 P0DP23 1/20 0.33
TP53 P04637 1/20 0.33
MDM2 Q00987 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bromide SCHEMBL29099283 0.98 CYP19A1 (0.35) CYP19A1SIGMAR1MEN1KMT2AALDH1A1
SCHEMBL28051889 0.83 SLC6A3 (0.41) SIGMAR1MEN1KMT2ATSHRTP53
SCHEMBL28139788 0.80 LMNA (0.38) ALDH1A1LMNASMN1; SMN2
SCHEMBL29021517 0.80 GSK3B (0.36) CYP19A1SIGMAR1MEN1KMT2AALDH1A1
SCHEMBL27507721 0.78 SIGMAR1 (0.38) CYP19A1SIGMAR1MEN1KMT2AALDH1A1
SCHEMBL27515932 0.76 ACHE (0.41) SIGMAR1ALDH1A1LMNAMAPTELANE
SCHEMBL5610169 0.76 SIGMAR1 (0.36) CYP19A1SIGMAR1MEN1KMT2AALDH1A1
Bromide SCHEMBL27410484 0.75 SIGMAR1 (0.35) CYP19A1SIGMAR1MEN1KMT2AALDH1A1
Bromide SCHEMBL27722888 0.75 ACHE (0.40) SIGMAR1ALDH1A1LMNAMAPTELANE
Hydrochloric Acid SCHEMBL28350609 0.75 ACHE (0.40) SIGMAR1ALDH1A1LMNAMAPTELANE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113717099-A Bromination reaction method and application of nitrogen-containing heterocyclic compound 四川大学 2021-11-30 CN claimed
CN-113717099-B Method for bromination reaction of nitrogen-containing heterocyclic compound and application 四川大学 2023-06-27 CN disclosed
CN-113717099-B Method for bromination reaction of nitrogen-containing heterocyclic compound and application 四川大学 2023-06-27 CN disclosed
CN-113717099-A Bromination reaction method and application of nitrogen-containing heterocyclic compound 四川大学 2021-11-30 CN disclosed
CN-113717099-A Bromination reaction method and application of nitrogen-containing heterocyclic compound 四川大学 2021-11-30 CN disclosed
CN-113527189-A Pyridine-3-formaldehyde compound and preparation method thereof 四川大学 2021-10-22 CN disclosed