Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CKS1B | P61024 | 3/20 | 0.38 |
| ▸ | SKP1 | P63208 | 3/20 | 0.38 |
| ▸ | SKP2 | Q13309 | 3/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | RBP4 | P02753 | 2/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28659973 | 1.00 | CKS1B (0.38) | CKS1BSKP1SKP2CHRM4KDM4E | |
| SCHEMBL28640864 | 0.90 | CKS1B (0.43) | CKS1BSKP1SKP2KDM4EPKM | |
| SCHEMBL28640862 | 0.90 | CKS1B (0.43) | CKS1BSKP1SKP2KDM4EPKM | |
| SCHEMBL28647418 | 0.79 | RBP4 (0.38) | RBP4LPLLIPGTTR | |
| SCHEMBL28653070 | 0.79 | RBP4 (0.38) | RBP4LPLLIPGTTR | |
| SCHEMBL28653069 | 0.79 | RBP4 (0.38) | RBP4LPLLIPGTTR | |
| SCHEMBL28647415 | 0.79 | RBP4 (0.38) | RBP4LPLLIPGTTR | |
| SCHEMBL28642826 | 0.77 | RORC (0.34) | — | |
| SCHEMBL28642829 | 0.77 | RORC (0.34) | — | |
| SCHEMBL28926895 | 0.72 | CKS1B (0.49) | CKS1BSKP1SKP2KDM4EPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113527298-A | Macrocyclic lactam derivative, preparation method and application thereof | 浙江海正药业股份有限公司 | 2021-10-22 | — | — | CN | disclosed |