Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CKS1B | P61024 | 1/20 | 0.43 |
| ▸ | SKP1 | P63208 | 1/20 | 0.43 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | ACACB | O00763 | 9/20 | 0.41 |
| ▸ | ACACA | Q13085 | 8/20 | 0.41 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 3/20 | 0.37 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28640862 | 1.00 | CKS1B (0.43) | CKS1BSKP1SKP2DRD2ACACB | |
| SCHEMBL28659973 | 0.90 | CKS1B (0.38) | CKS1BSKP1SKP2KDM4EPKM | |
| SCHEMBL28659971 | 0.90 | CKS1B (0.38) | CKS1BSKP1SKP2KDM4EPKM | |
| SCHEMBL28642826 | 0.88 | RORC (0.34) | DRD2ACACBRORC | |
| SCHEMBL28642829 | 0.88 | RORC (0.34) | DRD2ACACBRORC | |
| SCHEMBL28926895 | 0.83 | CKS1B (0.49) | CKS1BSKP1SKP2DRD2ACACB | |
| SCHEMBL8214675 | 0.80 | CKS1B (0.49) | CKS1BSKP1SKP2DRD2ACACB | |
| SCHEMBL28648284 | 0.79 | CKS1B (0.45) | CKS1BSKP1SKP2DRD2ACACB | |
| SCHEMBL28647415 | 0.79 | RBP4 (0.38) | — | |
| SCHEMBL28647418 | 0.79 | RBP4 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113527298-A | Macrocyclic lactam derivative, preparation method and application thereof | 浙江海正药业股份有限公司 | 2021-10-22 | — | — | CN | disclosed |