Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 2/20 | 0.51 |
| ▸ | PIM1 | P11309 | 2/20 | 0.43 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.43 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.37 |
| ▸ | HSP90B1 | P14625 | 3/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | TRAP1 | Q12931 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA3 | P07451 | 1/20 | 0.34 |
| ▸ | CA6 | P23280 | 1/20 | 0.34 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12820378 | 0.91 | ROCK2 (0.44) | ROCK2PIM1PIM2DGAT1HSP90AA1 | |
| SCHEMBL12820377 | 0.87 | HSP90AA1 (0.52) | ROCK2PIM1PIM2DGAT1HSP90AA1 | |
| SCHEMBL1317647 | 0.77 | DGAT1 (0.55) | DGAT1ALDH1A1KDM4EMEN1MAPT | |
| SCHEMBL30847414 | 0.77 | ROCK2 (0.39) | ROCK2PIM1PIM2KDM4EMAPT | |
| SCHEMBL27112718 | 0.77 | ROCK2 (0.39) | ROCK2PIM1PIM2KDM4EMAPT | |
| SCHEMBL28663872 | 0.75 | ROCK2 (0.45) | ROCK2PIM1PIM2HSP90AA1ROCK1 | |
| SCHEMBL23723698 | 0.74 | DGAT1 (0.48) | DGAT1KDM4EMEN1MAPTKMT2A | |
| SCHEMBL2775670 | 0.74 | ROCK2 (0.38) | ROCK2PIM1PIM2KMT2ACA1 | |
| SCHEMBL21478688 | 0.74 | PIM1 (0.46) | ROCK2PIM1PIM2HSP90AA1ALDH1A1 | |
| SCHEMBL23494625 | 0.74 | PIM1 (0.46) | ROCK2PIM1PIM2HSP90AA1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113767106-B | Oxazaquinazolin-7 (8H) -ones, preparation method and medical application thereof | 劲方医药科技(上海)有限公司 | 2024-02-20 | — | — | CN | disclosed |
| US-20220251109-A1 | OXAAZAQUINAZOLINE-7(8H)-KETONE COMPOUND, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL APPLICATION THEREOF | GENFLEET THERAPEUTICS (SHANGHAI) INC. (CN) | 2022-08-11 | — | — | US | disclosed |
| EP-3964516-A1 | OXAAZAQUINAZOLINE-7(8H)-KETONE COMPOUND, PREPARATION METHOD THERFOR AND PHARMACEUTICAL APPLICATION THEREOF | Genfleet Therapeutics (Shanghai) Inc. (CN) | 2022-03-09 | — | — | EP | disclosed |
| CN-113767106-A | Oxaazaquinazolin-7 (8H) -ones, their preparation and pharmaceutical use | 劲方医药科技(上海)有限公司 | 2021-12-07 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220251109-A1 | OXAAZAQUINAZOLINE-7(8H)-KETONE COMPOUND, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL APPLICATION THEREOF | KRAS, NRAS, WEE1 | ROCK2 1491/4885PIM1 1277/4885PIM2 1757/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.