SCHEMBL2866437

SCHEMBL2866437

O=C(OCCl)C(c1ccccc1)c1ccccc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRM1 P11229 4/20 0.56
CHRM3 P20309 4/20 0.56
CHRM2 P08172 3/20 0.56
CHRM4 P08173 3/20 0.56
KLK7 P49862 3/20 0.54
CYP1A2 P05177 2/20 0.53
CYP2D6 P10635 2/20 0.53
LMNA P02545 2/20 0.53
L3MBTL1 Q9Y468 3/20 0.52
TDP1 Q9NUW8 2/20 0.52
ALDH1A1 P00352 6/20 0.51
CYP3A4 P08684 2/20 0.51
SMN1; SMN2 Q16637 1/20 0.51
TP53 P04637 1/20 0.48
PKM P14618 1/20 0.48
NFKB1 P19838 1/20 0.48
THPO P40225 1/20 0.48
HIF1A Q16665 1/20 0.48
POLB P06746 1/20 0.47
KMT2A Q03164 2/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2864950 0.84 CHRM1 (0.62) CHRM1CHRM3CHRM2CHRM4KLK7
SCHEMBL16904038 0.82 CYP2D6 (0.43) CHRM1CHRM3CHRM2CHRM4KLK7
SCHEMBL2866421 0.81 CYP1A2 (0.59) CHRM1CHRM3CHRM2CHRM4KLK7
SCHEMBL12987446 0.80 KMT2A (0.46) CHRM1CHRM3CHRM2CHRM4CYP1A2
SCHEMBL12855131 0.80 CYP2D6 (0.46) CHRM1CHRM3CHRM2CHRM4CYP1A2
SCHEMBL2333882 0.80 KMT2A (0.46) CHRM1CHRM3CHRM2CHRM4CYP1A2
SCHEMBL14533664 0.80 CYP2D6 (0.46) CHRM1CHRM3CHRM2CHRM4CYP1A2
SCHEMBL12987109 0.80 KMT2A (0.46) CHRM1CHRM3CHRM2CHRM4CYP1A2
SCHEMBL2859452 0.80 CHRM1 (0.57) CHRM1CHRM3CHRM2CHRM4KLK7
SCHEMBL7956514 0.79 CHRM1 (0.56) CHRM1CHRM3CHRM2CHRM4KLK7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2822938-B1 RODENTICIDAL NORBORMIDE ANALOGUES LANDCARE RES NEW ZEALAND LIMITED (NZ) 2019-07-03 EP disclosed
EP-1795581-B1 LUBRICATING OIL COMPOSITION CONTAINING ACRYLIC POLYMER KURARAY CO (JP) 2018-09-19 EP disclosed
US-9198420-B2 Rodenticidal norbormide analogues LANDCARE RESEARCH NEW ZEALAND LIMITED (NZ) 2015-12-01 US disclosed
US-20150025113-A1 RODENTICIDAL NORBORMIDE ANALOGUES ANIMAL CONTROL PRODUCTS LIMITED (NZ) 2015-01-22 US disclosed
EP-2822938-A1 RODENTICIDAL NORBORMIDE ANALOGUES Landcare Research New Zealand Limited (NZ) 2015-01-14 EP disclosed
WO-2013133726-A1 RODENTICIDAL NORBORMIDE ANALOGUES LANDCARE RESEARCH NEW ZEALAND LIMITED (NZ) 2013-09-12 WO disclosed
US-7718588-B2 Lubricating oil additive containing acrylic polymer and lubricating oil compositions KURARAY CO., LTD. (JP) 2010-05-18 US disclosed
US-20080058234-A1 Lubricating Oil Additive Containing Acrylic Polymer and Lubricating Oil Compositions KURARAY CO., LTD. (JP) 2008-03-06 US disclosed
EP-1795581-A1 LUBRICATING OIL ADDITIVE CONTAINING ACRYLIC POLYMER AND LUBRICATING OIL COMPOSITIONS KURARAY CO., LTD. (JP) 2007-06-13 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150025113-A1 RODENTICIDAL NORBORMIDE ANALOGUES CASP7, RANBP1, CASP3 CHRM1 3974/4885CHRM3 2726/4885CHRM2 3578/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.