SCHEMBL28669997

SCHEMBL28669997

COc1ccc(C(=O)C2(O)CCCCC2)cc1

nearest known ligand 0.55

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CES2 O00748 2/20 0.52
CES1 P23141 2/20 0.52
CA1 P00915 5/20 0.50
CA2 P00918 5/20 0.50
ALDH1A1 P00352 2/20 0.49
KDM4E B2RXH2 1/20 0.49
MAPT P10636 1/20 0.49
TSHR P16473 1/20 0.49
HPGD P15428 1/20 0.49
PARP1 P09874 1/20 0.48
PARP10 Q53GL7 1/20 0.48
PARP2 Q9UGN5 1/20 0.48
PARP4 Q9UKK3 1/20 0.48
MEN1 O00255 1/20 0.48
KMT2A Q03164 1/20 0.48
PLK1 P53350 1/20 0.46
ALOX15 P16050 1/20 0.45
HTT P42858 1/20 0.45
SMN1; SMN2 Q16637 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Anisole SCHEMBL28254947 0.88 KDM4E (0.52) CES2CES1CA1CA2ALDH1A1
SCHEMBL17853888 0.85 TSHR (0.41) ALDH1A1KDM4EMAPTTSHRHPGD
SCHEMBL14040096 0.82 CES2 (0.52) CES2CES1CA1CA2ALDH1A1
SCHEMBL28505006 0.81 RAB9A (0.41) ALDH1A1MAPTHPGDMEN1KMT2A
SCHEMBL256587 0.81 ALDH1A1 (0.45) CES2CES1ALDH1A1KDM4EHPGD
SCHEMBL10943813 0.81 CES2 (0.39) CES2CES1
SCHEMBL6696391 0.81 SRD5A2 (0.39) ALDH1A1KDM4EMAPTTSHRHPGD
SCHEMBL4611297 0.81 GSK3B (0.51) CES2CES1CA1CA2ALDH1A1
SCHEMBL14040099 0.81 CES2 (0.50) CES2CES1CA1CA2ALDH1A1
SCHEMBL10384839 0.81 CES2 (0.50) CES2CES1CA1CA2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109369406-B Photocatalytic synthesis method and application of 1-hydroxycyclohexyl phenyl ketone compound 甘肃金盾化工有限责任公司 2021-12-14 CN disclosed