Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.53 |
| ▸ | CKS1B | P61024 | 2/20 | 0.49 |
| ▸ | SKP1 | P63208 | 2/20 | 0.49 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.49 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.49 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | DTYMK | P23919 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | TACR1 | P25103 | 1/20 | 0.46 |
| ▸ | STS | P08842 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27872075 | 0.85 | GPR119 (0.44) | GPR119CKS1BSKP1SKP2CHRM2 | |
| SCHEMBL27906266 | 0.82 | TSHR (0.57) | KDM4EPOLBKMT2AMAPTALDH1A1 | |
| SCHEMBL17523154 | 0.80 | MGLL (0.56) | KDM4EPOLBMEN1KMT2AALDH1A1 | |
| SCHEMBL7666266 | 0.79 | KMT2A (0.51) | CKS1BSKP1SKP2KMT2AALDH1A1 | |
| SCHEMBL955395 | 0.79 | SMN1; SMN2 (0.40) | CHRM4CHRM1CHRM3MEN1KMT2A | |
| SCHEMBL1458887 | 0.78 | GPR119 (0.76) | GPR119CKS1BSKP1SKP2MEN1 | |
| SCHEMBL952359 | 0.78 | GAA (0.60) | GPR119CKS1BSKP1SKP2CHRM2 | |
| SCHEMBL1374093 | 0.78 | MEN1 (0.68) | GPR119KDM4EPKMPOLBMEN1 | |
| SCHEMBL3397463 | 0.78 | GPR119 (0.50) | GPR119CHRM3KDM4EPKMMEN1 | |
| SCHEMBL13464773 | 0.77 | KDM4E (0.55) | GPR119CKS1BSKP1SKP2CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022246092-A1 | MACROCYCLIC COMPOUNDS FOR TREATING DISEASE | BLOSSOMHILL THERAPEUTICS, INC. (US) | 2022-11-24 | — | — | WO | disclosed |
| CN-104693193-A | Arylmethoxy isoindoline derivatives and compositions comprising and methods of using the same | CELGENE CORP | 2015-06-10 | — | — | CN | disclosed |
| CN-102822165-B | Arylmethoxy isoindoline derivatives and compositions comprising and methods of using the same | CELGENE CORP | 2015-02-25 | — | — | CN | disclosed |
| CN-102822165-A | Arylmethoxy isoindoline derivatives and compositions comprising and methods of using the same | CELGENE CORP | 2012-12-12 | — | — | CN | disclosed |
| CN-102480943-A | Opsin binding ligands, compositions and methods of use | BIKAM PHARMACEUTICALS INC | 2012-05-30 | — | — | CN | disclosed |
| US-7795267-B2 | Bicyclic piperazine compound having TGR23 antagonistic activity | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-14 | — | — | US | disclosed |
| US-20070072865-A1 | Bicyclic piperazine compound and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-03-29 | — | — | US | disclosed |
| EP-1661898-A1 | BICYCLIC PIPERAZINE COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2006-05-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070072865-A1 | Bicyclic piperazine compound and use thereof | GPR3, FFAR3, LPAR3 | GPR119 75/4885CKS1B 2809/4885SKP1 1883/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.