Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.30 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.30 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.30 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.30 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.30 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.30 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.30 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.30 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.30 |
| ▸ | PDE4A | P27815 | 1/20 | 0.30 |
| ▸ | SLC6A6 | P31641 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | BLM | P54132 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piperazine SCHEMBL8991321 | 0.89 | TSHR (0.42) | TSHRMEN1KMT2ALMNACYP3A4 | |
| Piperazine SCHEMBL28077828 | 0.87 | TSHR (0.41) | TSHRMEN1KMT2ALMNACYP3A4 | |
| Aziridine SCHEMBL29141899 | 0.87 | TSHR (0.43) | TSHRMEN1KMT2ALMNACYP3A4 | |
| Propene SCHEMBL28059885 | 0.87 | LMNA (0.38) | TSHRMEN1KMT2ALMNAPTGS1 | |
| Piperazine SCHEMBL28182579 | 0.85 | TSHR (0.39) | TSHRMEN1KMT2ALMNACYP3A4 | |
| Propene SCHEMBL28087209 | 0.85 | LMNA (0.36) | LMNAPTGS1PDE4ASLC6A6CYP2C19 | |
| Piperazine SCHEMBL29112098 | 0.82 | MEN1 (0.35) | TSHRMEN1KMT2APTGS1PDE4A | |
| Piperidine SCHEMBL4434690 | 0.79 | ALDH1A1 (0.39) | TSHRMEN1KMT2ALMNACYP3A4 | |
| SCHEMBL28481099 | 0.78 | LMNA (0.43) | TSHRMEN1KMT2ALMNAPTGS1 | |
| Piperazine SCHEMBL29137239 | 0.77 | APP (0.41) | TSHRMEN1KMT2ALMNACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113694174-A | Eye drop for preventing and treating cataract and preparation method thereof | 陈帝江 | 2021-11-26 | — | — | CN | disclosed |