Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | PDE4A | P27815 | 2/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | SLC6A6 | P31641 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.36 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piperazine SCHEMBL28077828 | 0.98 | TSHR (0.41) | TSHRMEN1KMT2ALMNAPDE4A | |
| Aziridine SCHEMBL29141899 | 0.97 | TSHR (0.43) | TSHRMEN1KMT2ALMNAPDE4A | |
| Piperazine SCHEMBL28182579 | 0.95 | TSHR (0.39) | TSHRMEN1KMT2ALMNAPDE4A | |
| Piperazine SCHEMBL28675666 | 0.89 | TSHR (0.36) | TSHRMEN1KMT2ALMNAPDE4A | |
| Piperidine SCHEMBL4434690 | 0.89 | ALDH1A1 (0.39) | TSHRMEN1KMT2ALMNAPDE4A | |
| Piperazine SCHEMBL29112098 | 0.88 | MEN1 (0.35) | TSHRMEN1KMT2APDE4APTGS1 | |
| Piperazine SCHEMBL29137239 | 0.86 | APP (0.41) | TSHRMEN1KMT2ALMNAPDE4A | |
| Morpholine SCHEMBL546850 | 0.85 | MEN1 (0.42) | TSHRMEN1KMT2ALMNAPDE4A | |
| Piperazine SCHEMBL28134580 | 0.84 | LMNA (0.43) | TSHRLMNAPDE4APTGS1SLC6A6 | |
| Piperazine SCHEMBL572783 | 0.84 | TSHR (0.42) | TSHRMEN1KMT2ALMNAPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110346316-A | It is coupled the method and assay kit of pyruvate oxidation enzymatic determination sialic acid (SIA) | 浙江力耐得传动科技有限公司 | 2019-10-18 | — | — | CN | claimed |
| CN-108601848-A | Efficient methods for preparing cell-binding agent-cytotoxic agent conjugates | 伊缪诺金公司 | 2018-09-28 | — | — | CN | claimed |
| CN-107592813-A | Method for preparing cell binding agent cytotoxic agent conjugate | 伊缪诺金公司 | 2018-01-16 | — | — | CN | claimed |
| CN-115521998-B | Triazine type chromium-free tanning agent and preparation method and application thereof | 南京工业大学 | 2024-01-02 | — | — | CN | disclosed |
| CN-115521998-A | Triazine type chromium-free tanning agent and preparation method and application thereof | 南京工业大学 | 2022-12-27 | — | — | CN | disclosed |
| CN-110366431-A | Maytansinoid derivatives with self-cleaving peptide linker and conjugates thereof | 伊缪诺金公司 | 2019-10-22 | — | — | CN | disclosed |
| CN-109922793-A | Poorly water soluble dietary supplements and methods of solubilizing pharmaceutically active agents | 雅典娜股份公司 | 2019-06-21 | — | — | CN | disclosed |
| CN-109200290-A | Use pvdf membrane purifying cells bonding agent cytotoxic agent conjugate | 伊缪诺金公司 | 2019-01-15 | — | — | CN | disclosed |
| CN-107592813-A | Method for preparing cell binding agent cytotoxic agent conjugate | 伊缪诺金公司 | 2018-01-16 | — | — | CN | disclosed |
| CN-107567437-A | Crystalline form of 5-amino-2, 3-dihydrophthalazine-1, 4-dione sodium salt, pharmaceutical preparation containing it and process for its production | 麦翠奥制药公司 | 2018-01-09 | — | — | CN | disclosed |
| CN-105669593-A | Barium base metal organic framework material preparation method | 中国科学院大连化学物理研究所 | 2016-06-15 | — | — | CN | disclosed |
| CN-104011537-A | Electrophoresis buffer for extending useful electrophoresis life of electrophoresis gel | DGEL ELECTROSYSTEM INC | 2014-08-27 | — | — | CN | disclosed |
| EP-0717645-A1 | REDUCTION OF SKIN IRRITATION AND RESISTANCE DURING ELECTROTRANSPORT | ALZA CORPORATION (US) | 1996-06-26 | — | — | EP | disclosed |
| WO-1995006497-A1 | REDUCTION OF SKIN IRRITATION AND RESISTANCE DURING ELECTROTRANSPORT | ALZA CORPORATION (US) | 1995-03-09 | — | — | WO | disclosed |